0 Nour S. A.; Nafadi M. M. and Abd-El Malak N. S. Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Cairo University, Cairo, Egypt.

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0 Nour S. A.; Nafadi M. M. and Abd-El Malak N. S. Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Cairo University, Cairo, Egypt.

Aim of work The objective of this study was formulation of controlled drug release beads by loading the anti inflammatory ketorolac tromethamine (KT) to gelrite natural polymer as a drug carrier. Eight formulations were prepared adopting 2 3 factorial design.

Conclusion the formula of choice was that prepared with 2% gelrite, air dried and subjected to wax treatment (FIII), FIII showed a lower ulcer index when compared to KT powder and the commercial formula(FB), due to microencapsulation process and the protective effect of the natural polymer used on GIT. The prepared beads showed very good correlation between the in-vitro release studies and their anti-inflammatory effect.

Table (1): Different Formulae of Ketorolac Tromethamine Beads Prepared Using Gelrite and 1% Drug (2 3 Factorial Design). * At 40 o C for 24 hours. Wax Treatment Gelrite Concentration(%W/V) Drug : Polymer Ratio Drying MethodFormula Absent 2 1:2 Air DryingFI AbsentOven Drying*FII PresentAir DryingFIII PresentOven Drying*FIV Absent 4 1:4 Air DryingFV AbsentOven Drying*FVI PresentAir DryingFVII PresentOven Drying*FVIII