Principles of Immunology Tumor Immunology 4/25/06

Word/Terms List  AFP  Benign  Carcinoma  CEA  Leukemia  Lymphoma  Malignant  Metastasis  Neoplasm  Oncogene  Sarcoma  Transformation  TSTA

Tumor Immunology Benign vs. malignant tumors Types of neoplasms  Carcinomas  Leukemias/lymphomas  Sarcomas

Cell Transformation Characteristics  Nutritional changes  Lack of contact inhibition  Immortality

Chemicals and Cancer  Mitogens  Mutagens  Carcinogens

Genes and Cancer  Oncogenes  Proto-oncogenes

Tumor-specific Transplantation Antigens Origin of TSTAs  Point mutations  Expressed by germ line cells  Expressed by specific cell types  Over expressed  Post translation changes  Viral oncogenes

Oncofetal Antigens  Alpha fetoprotein (AFP)  Carcinoembryonic antigen (CEA)

Tumors of the Immune System  Leukemias ALL AML CLL CML  Lymphomas

Tumors and Viruses  Hepatitis B  Human papilloma virus(HPV)  Epstein Barr Virus

Tumors and Evasion of the Immune System  Low immunogenicity  Modulation by antibodies  Tumor secreted suppressors

Immune Response to Tumors  Cells NK CTLs Macrophages  Cytokines Interferon TNF

Immunotherapy Against Tumors  ADCC  Toxin conjugation  Radionuclide conjugation