Bimonthly Meeting on August 22, 2008 Chemical Information on Brain Tissue by Different Methods Amarjeet Bhullar.

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Presentation transcript:

Bimonthly Meeting on August 22, 2008 Chemical Information on Brain Tissue by Different Methods Amarjeet Bhullar

We have compared metabolite ratios, calculated using three different methods: Directly Generated by Functool Metabolites Concentration Generated by Functool Gaussian Function Overlapped on metabolite peak

S19.6 Exam ID: 4465 June 23, 2008 Patient Name: AD

Mathematical Model: Gaussian Function

We can solve this integral by numerically and by explicit expression Explicit Expression Numerically

How to compute metabolite concentration Spectrum

Concentration of the Choline Cho=Area under the curve between 3.34 and 3.19 PPM

Concentration of the Creatine Cre=Area under the curve between 3.16 and 3.00 PPM

Concentration of the NAA NAA=Area under the curve between 2.19 and 2.02 PPM

Voxel #23Functool-1Functool-2Our Calculation Cho/Cre Cho/NAA Chemical Information on Voxel # 23

Voxel #24Functool-1Functool-2Our Calculation Cho/Cre Cho/NAA Chemical Information on Voxel # 24

Voxel #25Functool-1Functool-2Our Calculation Cho/Cre Cho/NAA Chemical Information on Voxel # 25

Voxel #26Functool-1Functool-2Our Calculation Cho/Cre Cho/NAA Chemical Information on Voxel # 26

Voxel #27Functool-1Functool-2Our Calculation Cho/Cre Cho/NAA Chemical Information on Voxel # 27

Voxel #25Functool-1Functool-2Our Calculation Cho/Cre Cho/NAA Chemical Information on Voxel # 30

Conclusion : There is no significant difference between our calculation and Functool. Suggestions are welcome

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