Huntington’s Disease II: Genetics and cell pathology Neurobiology of Disease.

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Presentation transcript:

Huntington’s Disease II: Genetics and cell pathology Neurobiology of Disease

Gusella, Wexler and colleagues identify locus Huntintin cloned, CAG, poly Q repeats identified

Myers 2004 NeuroRx. 1:

Paulson Fischbeck Annu. Rev. Neurosci :79-107

Mutant mice:

Rubinsztein 2002

Harjes, Wanker Trends Biochem. Sci. 28:425

Landles,Bates 2004 EMBO Reports 5:958

Landles,Bates 2004 EMBO Reports 5:958

Neurotrophins and Receptors NGF BDNF NT4/5 NT3 NGF BDNF NT3 NT4/5 TrkA TrkB TrkC p75 NTR (Adapted from Neet & Campenot, 2001)

Bacquet et al J Neurosci. 24:4250-8

Arrasate et al Nature 431:805

Fig. 2

Gauthier et al Fig. 1

Schroer 2004