1 Research Update LAE 12/5/08. 2 Variation of Lesion Intensity with Lesion Location Concerned about assumption stated in manuscript that uncertainty in.

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1 Research Update LAE 12/5/08

2 Variation of Lesion Intensity with Lesion Location Concerned about assumption stated in manuscript that uncertainty in lesion location is equal to uncertainty in lesion intensity (see page 5 of current draft). In patient #2 (D),lesion location was varied and resulting intensity variation was noted.

3 X_min=33 Y_max=206 Y_min=19 X_max=187  x = 154  y = 187 Lesion location varied in X and y direction and resulting Intensity variation observed

4 Variation of Lesion Intensity with Lesion Location: Results Area(pxl 2 )Mn Int% dev x% dev y% dev Mn Int