Gene Chasing with the Hierarchical Clustering Explorer: Finding Meaningful Clusters in High Dimensional Data Jinwook Seo and Ben Shneiderman HCIL

Understanding Clusters Cluster Identification –How to identify interesting clusters –Interactive exploration of clustering results Understanding Clusters –Expert’s domain knowledge –Intuitive search mechanisms –Overlap of clusters and search results

Time 0 12Hr 1Day 2Day ……………………………. 30Day 40Day Measure the activities of 12,422 genes at 27 time points Mouse Muscle Regeneration

Clustering Result Overview Genes Time

Searching for Clusters Minimum Similarity Bar

Searching for Clusters

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Hierarchical Clustering Explorer 1400 downloads since April 2002 – –1 commercial license to a biotech company Demonstration at HCIL1 Try HCE to analyze your multidimensional data –3138 US Counties –Demographic data Sponsored by Children’s National Medical Center