1 Diabetes. 2 Human Digestive System 3 Normal Regulation of Blood Glucose

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Presentation transcript:

1 Diabetes

2 Human Digestive System

3 Normal Regulation of Blood Glucose

4 Pancreas: 2 Organs in 1 90% Exocrine 10% Endocrine

5 Endocrine pancreas releases hormones to control blood sugar

6 Glucose > Insulin Release

7 Insulin Action

8 Hormones Help Insulin Nature 452, (24 April 2008)

9 Hemoglobin A1c best indicator of control over the preceding 4-6 weeks formed when a glucose molecule becomes permanently bound to a hemoglobin molecule amount formed depends on the average level of blood glucose the hemoglobin is exposed to life span of a red blood cell in the blood stream = 120 days

10 Pathogenesis of Type 1

11 Obesity Trends* Among U.S. Adults BRFSS, 1990, 1998, 2007 (*BMI 30, or about 30 lbs. overweight for 5’4” person) No Data <10% 10%–14% 15%–19% 20%–24% 25%–29% ≥30%

12 Metabolic management of type 2 diabetes D IABETES C ARE, VOLUME 31, NUMBER 1, J ANUARY 2008