Septal activation impaired the retrieval of a previously stored hippocampal place cell representation regardless of age. When the environment was changed,

Slides:



Advertisements
Similar presentations
Acetylcholine (ACH) Acetyl-CoA + Cholin ACH +CoA
Advertisements

NSF Science of Learning Lila Davachi Dept Psychology and Neural Science New York University.
192-IgG Saporin lesions of the medial septum or nucleus basalis magnocellularis disrupt exploratory trip organization. D.G. Wallace*, S.S. Winter, M.M.
The Memory Function of Sleep Week 14 Group 4 Kindra Akridge Kimberly Villalva Zhiheng Zhou.
Cellular Mechanisms of Learning
Neural Basis of Cognition Lecture 6 Learning and Memory, Part II.
Odor Cues During Slow-Wave Sleep Prompt Declarative Memory Consolidation Rasch, B., Buchel, C., Gais, S., & Born, J. Presented by: Suiki Zhang.
Dissociable neural mechanisms supporting visual short-term memory for objects Xu, Y. & Chun, M. M. (2006) Nature, 440,
Optical controlling reveals time- dependent roles for adult-born dentate granule cells Yan Gu, Maithe Arruda-Carvalho, Jia Wang, Stephen R Janoschka, Sheena.
EFFECTS OF INTRASEPTAL CARBACHOL ON BURST PROPERTIES OF CA1 PYRAMIDAL NEURONS S. Sava 1,2 *, G.J. Peters 1,3, E.J. Markus 1 1 Psych. Dept., Univ of Conn.,
Mode shifting between storage and recall based on novelty detection in oscillating hippocampal circuits M. Meeter J. M. J. Murre L. M. Talamini Date of.
Methods Results Conclusions Selective cholinergic lesions of the medial septum disrupt dead reckoning based navigation M.M. Martin*; M.D. Schultz; S.S.
DECLARATIVE MEMORY IN ANIMALS 1.Research aims of animal models a. Neuropsychological aim b.Comparative aim c.Neurobiological mechanisms 2. Limitations.
Research interests and techniques: Neuroscience: molecular biology; transgenics, neuroanatomy, physiology, behaviour. Hippocampal function: parvalbuminergic.
Methods Results Conclusions Selective hippocampal cholinergic deafferentation disrupts exploratory trip organization D.G. Wallace*; S.K. Knapp; J.A. Silver;
Methods Results Conclusions Walking the plank: Role of the medial septum in distance estimation S.S. Winter; M.M. Martin; D.G. Wallace Dept Psychology,
WHY ARE THERE PARALLEL HIPPOCAMPAL - DIENCEPHALIC PATHWAYS FOR EVENT MEMORY? Wellcome Trust Project JOHN AGGLETON SHANE O’MARA JONATHAN ERICHSEN SERALYNNE.
Widely Found and Studied Neurotransmitters  Glutamate – has excitatory functions  4 Ascending activating systems are very important  Cholinergic System.
Electrical Synapses Control Hippocampal Contributions to Fear Learning and Memory Stephanie Bissiere, Moriel Zelikowsky, Ravikumar Ponnusamy, Nathan S.
PART 4: BEHAVIORAL PLASTICITY #24: SPATIAL NAVIGATION IN RATS I
IEG - Arc/Arg 3.1 Allatostatin receptor (AlstR) + 10 nM Alst GFP controlled by Arc/Arg 3.1 gene promoter Genetical strategy for silencing a memory-encoding.
Figure 4: Average dodger speeds are shown for MS (left panel) and NB (right panel) groups. Dodging (circles) and bracing (triangles) speeds are plotted.
Figure 5: Initial (left panel) and terminal (right panel) distances between the noses of the dodger and robber rats are plotted separately for dodging.
Memory Systems Chapter 23 Friday, December 5, 2003.
Alzheimer’s Disease Nicotine’s relationship and contribution to dementia.
Hippocampus and spatial memory A case study of Jon. King, J. A., Trinkler, I., Hartley, T., Vargha-Khadem, F., & Burgess, N. (2004). The Hippocampal Role.
Research by Wagner et al Presented by Daehan Choi.
The assessment of working memory in rodents Dr. Paul Dudchenko University of Stirling United Kingdom.
MCDONNELL PROJECT. ABSTRACT Plasticity mechanisms can alter the responses of neurons in the auditory cortex. Input-specific reorganization of primary.
Spatial Memory & Navigation Objectives: 1. To introduce spatial performance as a topic in psychological science 2. To illustrate how diverse psychological.
Neuromodulation: acetylcholine and memory consolidation Michael E. Hasselmo Trends in Cognitive Sciences – Vol. 3, No. 9, September 1999.
Acute effects of alcohol on neural correlates of episodic memory encoding Söderlund, H., Grady, C.L., Easdon, C. & Tulving, E. By Miranda Marchand.
The brain is impossibly complicated - if it were simple enough to understand, we'd be too simple to understand it. - Lyall Watson.
A HIGH-RESOLUTION STUDY OF HIPPOCAMPAL AND MEDIAL TEMPORAL LOBE CORRELATES OF SPATIAL CONTEXT AND PROSPECTIVE OVERLAPPING ROUTE MEMORY --T. BROWN, M. HASSELMO,
 The most commonly used illicit drug in the U.S.  95 million Americans, ages 12 or older have at least tried marijuana at some point.  ¾ illicit drug.
Acute effects of alcohol on neural correlates of episodic memory encoding Hedvig Söderlund, Cheryl L. Grady, Craig Easdon and Endel Tulving Sundeep Bhullar.
Part 6 Opener Simultaneous registration maps of EEG and functional MRI.
Age effects on hippocampal functional connectivity during multifeatural encoding Chris Foster 1, Milton Picklesimer 1, Neil Mulligan, Ph.D. 1, and Kelly.
Lecture 24 Learning and Memory II. Memories Long term memory stored in cortex Information is processed for memory storage in other brain regions (i.e.
Relational Learning and Amnesia
Week 14 The Memory Function of Sleep Group 3 Tawni Voyles Alyona Koneva Bayou Wang.
The effects of metabotropic glutamate receptors in NMDA receptor dependent long-term potentiation in hippocampus Zhou Su-ya.
Introduction  The Temporoammonic (TA) projection from entorhinal cortex (EC) layer III to the s. l-m. layer of the CA1 subregion is the direct source.
The Memory Function of Sleep Group 1 Amanda Ayoub Hannah Stolarczyk Stephanie Regan Alicia Iafonaro.
D ISTINCT C OMPONENTS OF S PATIAL L EARNING R EVEALED BY P RIOR T RAINING AND NMDA R ECEPTOR B LOCKADE Group B3 Abdullah, Barbara, Charles, Charmaine,
UNIT 3 THE CONSCIOUS SELF
Copyright © 2004 Allyn and Bacon 1 Chapter 13 Learning and Memory: Basic Mechanisms This multimedia product and its contents are protected under copyright.
The Memory Function of Sleep By: Susanne Diekelmann and Jan Born Youngjin Kang Alyssa Nolde Toni Sellers.
M. A. Wilson and B. L. McNaughton Presented by: Katie Herdman, Monika Walerjan, Scott Good, Snir Seitelbach and David Dudar.
Learning like a girl? “Estrogen modulates learning in female rats by acting directly at distinct memory systems” L. Zurkovsky et al. Neuroscience (2007)
Fear conditioning… e.g., Electric shock associated with specific stimuli.
By: Matthew A. Wilson & Bruce L. McNaughton GROUP A2: Anna Loza Elyse Rosa Britni Rowe Caroline Olsen Vedran Dzebic Kris Clark.
Geula & Mesulam, Cerebral Cortex 1996, 6: Age-matched controlAlzheimer’s disease.
Cognitive Impairment and Neural Pregenitor Cell Destruction (on Lister hooded rats) as a Result of Chemotherapy Morgan Earle, Department of Biological.
Cholinergic Modulation of the Hippocampus Computational Models of Neural Systems Lecture 2.5 David S. Touretzky September, 2007.
Theta, Gamma, and Working Memory
Hippocampal ‘‘Time Cells’’ Bridge the Gap in Memory for Discontiguous Events August, 2011.
Chapter 21 Spatial Behavior.
Methods Objectives Results Conclusions References
The temporal dynamics of switch between hippocampal attractor states
Volume 74, Issue 3, Pages (May 2012)
STORE MANAGER RESPONSIBILITIES.
Progress Seminar 권순빈.
The Role of Hippocampal Replay in Memory and Planning
Kevin G. Guise, Matthew L. Shapiro  Neuron 
Ch.8 Theta rhythm and bidirectional plasticity in the hippocampus
Volume 25, Issue 23, Pages R1116-R1121 (December 2015)
New and Distinct Hippocampal Place Codes Are Generated in a New Environment during Septal Inactivation  Mark P. Brandon, Julie Koenig, Jill K. Leutgeb,
CA2: It’s About Time—and Episodes
Relational Learning and Amnesia
Presentation transcript:

Septal activation impaired the retrieval of a previously stored hippocampal place cell representation regardless of age. When the environment was changed, medial septal activation impaired the encoding process in young, but facilitated the encoding of the new information in aged rats.

Effect of aging on hippocampal place cells

Medial septum and theta rhythm

Inactivation of the MS decreases hippocampal theta and spatial task performance. Intraseptal cholinergic drugs increase hippocampal theta power and can promote memory performance in scopolamine- treated or aged memory-impaired rats but not in young rats.

So… The present study examined whether increased MS activation (by intraseptal carbachol, a cholinergic agonist) would promote remapping, indicating the encoding or establishment of a new representation of the environment within the hippocampus.

YOUNG AGED CONTROLCARBACHOL

YOUNG AGED CONTROLCARBACHOL

Feedback: Privacy Policy Feedback
Do Not Sell My Personal Information
About project: SlidePlayer Terms of Service

© 2025 SlidePlayer.com. Inc. All rights reserved.