Lecture 12 August 26, 2005 Lehninger (4 th Edition), Chapter 17

FATTY ACID DEGRADATION (OXIDATION) LNC Chapter 17

LNC 10-1

LNC 10-6

LNC 10-8

LNC 10-15

LNC 10-16

UPTAKE and DISTRIBUTION in Mammals

LNC 17-1

LNC ADIPOSE TISSUE

LNC 17-2 Chylomicron

LNC 21-39a Structure of an LDL particle

LNC 21-39b

Breakdown/Oxidation of Fatty Acids  -Oxidation

Activation LNC 17-5

LNC 17-6

C 14 fatty acid 7 acetyl CoA 6 rounds of  oxidation

LNC 17-7

LNC 19-8

LNC 17-9 How to deal with unsaturated fatty acids: cis  3 - or double bond between 

LNC 17-10

LNC How to deal with a fatty acid containing an uneven number of carbons C3 C4

LNC box 17-1

LNC box 17-2

catalase Degradation of very long chain fatty acids in the peroxisome LNC 17-12

Glyoxalate Cycle in Plants LNC 17-13

Ketone Bodies

LNC Fig Conditions favoring ketone body formation: depletion of OA for gluconeogenesis acetyl-CoA becomes available for ketone body synthesis

Metabolic Biochemistry FATTY ACID SYNTHESIS LNC Chapter 21

LNC Fig the enzyme has three functional regions: - biotin carrier protein - biotin carboxylase - transcarboxylase acetyl-CoA + CO 2 ==> malonyl-CoA

LNC Fig. 21-4

acyl carrier protein LNC Fig. 21-2

End of lecture 12 August 26, 2005