Signal Pathways in Eukaryotic Cells Overview. Lipid Soluble Hormones.

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Presentation transcript:

Signal Pathways in Eukaryotic Cells Overview

Lipid Soluble Hormones

Nuclear Receptors Nuclear Receptors For Lipid Soluble Hormones Hsp90

Receptors for Extra Cellular Signaling Molecules (Water Soluble or Peptide )

More Trans-Membrane Receptors

Signal Transduction Systems

A Seven-Spanning G-Protein Linked Receptor

Activation of a heterotrimeric G-protein Liganded receptor promotes exchange of GDP for GTP in G alpha G alpha dissociates from G beta gamma (both are activated)

Activation of Effector Protein(s)

Inactivation of G-Protein

G-Proteins Can Activate Genes

Gs Alpha Activates Adenyl Cyclase

Protein Kinase A Phosphorylates CREB

Enzyme Linked Receptors:Tyrosine Kinases * * *

Liganded Tyrosine Kinase Receptors Dimerize and Auto- Phosphorylate

Activated TK Receptors Bind Adapter Proteins Which Regulate GTP Binding Proteins

Kinase Cascades Activate Genes & Regulate Proteins

The Protein Kinases are Evolutionarily Conserved

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