By Ryan Johnson

General Overview  NTD  >20% of human population infected  Locally underestimated  Public health crucial

Trichuris Nematodes Coevolved with Man  Infects old and new world monkeys  Discovered in 1740

Morphology

Fecal-Oral Transmission  Soil to mouth

Embryonic Development Must Occur Outside of the Human 3 weeks later I won’t be able to hatch in your stomach if you eat me now. Gimme 3 weeks! Time’s up… …EAT ME!!!

Signs and Symptoms  Light infestation – asymptomatic  Severe infestation – GI problems

Treatment  Mebendazole

Prevents Microtubule Polymerization

Preventive Chemotherapy  Heaviest burden on kids  Treatment 2x a year  1 dose = fraction USD

  Fernando, Ranjan L; Tropical infectious diseases : epidemiology, investigation, diagnosis and management; London : Greenwich Medical Media,   Hutchinson, et al; Clinical Trial of Mebendazole, A Broad-spectrum Anthelminthic; 8/pdf/brmedj pdf/?tool=pmcentrez 8/pdf/brmedj pdf/?tool=pmcentrez  Miller, et al; Mebendazole, An Effective Anthelmintic for Trichuriasis and Enterobiasis; assn.org/cgi/reprint/230/10/1412.pdf