Division of Genetic and Reproductive Toxicology Staff Research Focus Areas Senior Investigators Framework for Research.

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Presentation transcript:

Division of Genetic and Reproductive Toxicology Staff Research Focus Areas Senior Investigators Framework for Research

DGRT Staff 31.8 FTE Government positions 14 Research Scientists 3 Staff Fellows 12.8 Support Scientists 2 Administrative 6 ORISE Post Docs 1 ORISE Pre Doc

DGRT Research Focus Areas Genetic Toxicology Reproductive/ Developmental Toxicology Diet and Nutrition Genomics & Proteomics

Senior Investigators-- Genetic Toxicology In vivo: Bob Heflich Ben Aidoo Tao Chen* Vasily Dobrovolsky* Jim Fuscoe Magomed Khaidakov** Manju Manjanatha Page McKinzie** Suzanne Morris Barbara Parsons* Carrie Valentine In vitro: Suzanne Morris Tao Chen* Bruce Hass TBN** * Staff Fellow ** Post Doc

Senior Investigators-- Reproductive/Developmental Toxicology Deb Hansen Bill Branham Ming Lu Dan Sheehan

Senior Investigators--Diet and Nutrition Ritchie Feuers Peter Duffy Varsha Desai** Ming Lu Ben Aidoo Deb Hansen Bob Heflich Sachin Bendre*** Suzanne Morris ** Post Doc ***Pre Doc

Senior Investigators-- Genomics and proteomics Jim Fuscoe Ritchie Feuers Angela Harris Varsha Desai** Suzanne Morris ** Post Doc

Framework for DGRT Research Basic Applied Research to Improve Regulatory Decision Making (Risk Assessment) Chemical Specific Information CFSAN CDER CBER CVM CDRH OWH

Framework for DGRT Research Basic Applied Research to Improve Regulatory Decision Making (Risk Assessment) --Hazard Characterization --Dose Response Assessment

Framework for DGRT Research Hazard Characterization --Develop new methods --Characterize/understand assays --Interpretation of data --Modes of action for toxicants --Rodent/human extrapolation --Develop guidelines

Framework for DGRT Research Hazard Characterization --Develop new methods TK+/- Mouse Model MutEx/ACB-PCR Genotypic Selection PhiX174 Gene Mutation Keratinocyte hprt Fluorescent Markers Endocrine Knowledge

Framework for DGRT Research Hazard Characterization --Characterize/understand assays --Interpretation of data In Vivo lacI and hprt Mouse Lymphoma TK Assay In Vivo Mouse TK Assay Human Lymphoblastoid TK Assay Filter Arrays

Framework for DGRT Research Hazard Characterization --Modes of action for toxicants DNA Sequence Analysis Chromosomal Mutations Genomic Rearrangements Folate & Neural Tube Development Impact of Dietary Restriction on Somatic Mutation and Physiological Parameters Gene Expression & Protein Production

Framework for DGRT Research Hazard Characterization --Rodent/human extrapolation Response to Dietary Restriction & Nutritional Changes Response of Hepatocytes to Toxicants

Framework for DGRT Research Mouse Lymphoma TK Assay In Vivo Gene Mutation Assays Hazard Characterization --Develop guidelines

Framework for DGRT Research Dose Response Assessment --Relevant doses --Susceptibility/variability --Rodent/human extrapolation --Cancer/noncancer --Quantitative models

Framework for DGRT Research Dose Response Assessment --Relevant doses Dose Selection Biomarkers Genomics/Proteomics

Framework for DGRT Research Dose Response Assessment --Susceptibility/variability Fetus/Newborn/ Young Child Diet: Antioxidants Dietary Restriction Phytoestrogens Repair Deficiency: PMS2-Mismatch Mice

Framework for DGRT Research Dose Response Assessment --Rodent/human extrapolation Liver Toxicity Biomarkers Diet and Nutrition Genomics/Proteomics

Framework for DGRT Research Dose Response Assessment --Cancer/noncancer --Quantitative models Mechanistic Commonality Genomics/Proteomics

Framework for DGRT Research Chemical Specific Information --Genistein --Coumestrol --Leucomalachite Green --AZT --UV light/Phototoxicity

Cross Agency Collaboration DGRT DBT DBRA CDER CFSAN OWH NIEHS NTP EPA ACADEMIA DNT