Lecture 2 CHE 618. Agonists Partial Agonist Antagonist Inverse Agonist.

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Presentation transcript:

Lecture 2 CHE 618

Agonists Partial Agonist Antagonist Inverse Agonist

+1 0 Functional Response Log[Drug] Full Agonist Partial Agonist Neutral Antagonist Full Inverse Agonist

Competitive Antagonism A1 + Receptor{A1 Receptor} effect A2 + Receptor {A2 Receptor}

R A1 A2 R A1 R A2 R A1 A2 Receptor-A1 is active Receptor-A1-A2 is active

Similar: In coordination chemistry Metal Ion + Ligand 1 + Ligand 2 In enzyme kinetics Enzyme + Substrate + Inhibitor

Dose-response curve What is there that is not poison? All things are poison and nothing without poison Solely the dose determines that a thing is not a poison