Aim of work The main objective of this investigation was to optimize the formulation of chitosan beads with Ketorolac tromethamine to minimize the gastrointestinal side effects of the drug and to prolong its release. Design the effect of the formulation variables on drug release.

CONCLUSION 1-The formulation variables, namely, chitosan concentration and stabilization time markedly influenced the drug content. Increasing chitosan concentration from 0.75 to 1.25 % and (SPP) concentration from 1 to 3 % significantly decreased the drug content of the beads. While, increasing the stabilization time from 30 to 90 min significantly increased the drug content.

2-Statistical analysis of the release data revealed that the increase in chitosan concentration from0.75 to 1.25 %, and stabilization time from 30 to 90 min increased significantly the t 50% of the drug. Kinetic analysis of the release data revealed that zero order and diffusion controlled mechanisms prevailed. 3-Based on the previous findings, it is evident that the preparation of the beads using chitosan,( SPP) and gluteraldehyde resulted in retardation of release of the highly water soluble KT.

4-The experimental design used was the factorial design Levels Variables Chitosan concentration(%) SPP concentration(%) Stabilization time Table(1): The Experimental Plan of the 3 3 Factorial Design.