SERONEGATIVE SPONDARTHRITIS ● Ankylosing spondylitis ● Psoriasis ● Reactive arthritis ● Reiters disease ● Ulcerative colitis ● Crohn’s disease ● (Whipple’s disease)

CHARACTERISTIC OF SERONEGATIVE SPONDARTHRITIDES Absence of rheumatoid Familial clustering factor Increased incidence Involvement of sacro- of HLA-B27 iliac and spinal joints Common spectrum Peripheral arthritis of extra-articular (predominantly features (pre- lower limb) dominantly muco- Enthesopathy cutaneous)

PATTERNS OF PSORIATIC ARTHROPATHY Distal interphalangeal joint disease with associated nail lesions. Seronegative polyarthritis often variable and assymetrical, may develop transient ‘sausage digits’. Deforming arthritis (‘arthritis mutilans’) Spondylitis

FEATURES OF REITERS DISEASE ● Urethritis ● Conjunctivitis ● Arthritis ● Enthesopathy ● Sacroiliitis ● Keratoderma blenorrhagica ● Mouth ulcers ● Circinate balanitis ● Cervicitis ● Iritis

FEATURES OF WHIPPLE’S DISEASE ● Malabsorption ● Arthritis ● Fever ● Lymphadenopathy