微生物應用工業 Ch5. 微生物催化劑阮雪芬 Nov 19, 2002 NTUT www.ntut.edu.tw/~yukijuan/lectures/Microbio/Nov19.ppt.

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Presentation transcript:

微生物應用工業 Ch5. 微生物催化劑阮雪芬 Nov 19, 2002 NTUT

Primary Structure

Peptide-bond Formation

Amino Acid Sequences Have Direction

Components of a Polypeptide Chain Backbone: constant Side chains: variable

Cross-links Disulfide bond

Amino Acid Sequence of Bovine Insulin

Peptide Bond Are Plane Side chain AA1 AA2

C-N single bond: 1.49 C=N double bond: 1.27

Secondary Structure

Structure of Alpha Helix

Schematic Views of alpha helices Ball-and-stick Ribbon Cyclindrical

Structure of a Beta Strand An antiparallel beta sheet A parallel beta sheet

Structure of a Mixed Beta Sheet

A Twisted beta Sheet

A Protein Rich in Beta Sheets The structure of a fatty acid-binding proteins

Structure of a Reverse Turn H bond Reverse turn is also known as the beta turn or hairpin bend

Loops on a Proteins Surface Unlike alpha helices and beta strands, loops do not have regular, periodic structure

Tertiary Structure

Three-dimensional Structure of Myoglobin The first protein to been seen in atomic detail.

Distribution of Amino Acids in Myoglobin : Hydrophobic amino acids : Charged amino acids : others

Protein Domains The cell-surface protein CD4 consists of four similar domains

Quaternary Structure

Dimer The Cro Protein of Bacteriophage Lamda

Tetramer