Suffering from Osteoporosis? - Mathematical modeling of bone remodeling at cellular level Yanan Wang 31/10/2007.

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Presentation transcript:

Suffering from Osteoporosis? - Mathematical modeling of bone remodeling at cellular level Yanan Wang 31/10/2007

Osteoporosis

 How does osteoporosis relate to my work (bone remodeling)?

Bone remodeling cycle at cellular level

Bone remodeling (Coupling)

Significance of bone remodeling  Serving to adjust bone architecture.  Helping to repair microdamage.  Maintaing plasma calcium homeostastis.

Logical structure of the model

Reasons for including PTH  PTH is currently involved in clinical trials.  PTH 1-34 was recently approved by the Food and Drug Administration of America (FDA).

Intermittent vs Continuous

Biomechanical control of bone remodeling

Effect of electromagnetic field on remodeling

Conclusion

The end Thank you