Effect of natural solubilizers on the solubility and dissolution of Aceclofenac By A. A. Osman*,, M. M. Nafadi.*, and N. D. Mortada** Department of Pharmaceutics, Faculty of Pharmacy, Cairo University* and Ain Shams University**

Aim of work In this work, attempts were made to enhance the solubility of the poorly soluble Aceclofenac and hence its bioavailability. To accomplish this work, Aceclofenac solid dispersions were prepared using the gall bladder contents of three species from three different animal classes, namely: Fishes, Aves and Mammalia(Tilabia nilotica, hen and rabbit) ) respectively as well as synthetic solubilizers.

The prepared solid dispersions were subjected to surface tension measurements, solubility and dissolution studies. Any interactions between the drug and the used solubilizers, if any, were studied using differential scanning calorimetry and infrared spectroscopy.

Conclusion 1- The results of this work revealed that the used micellar system enhanced the solubility of the drug as well as its dissolution, especially in acid medium. The enhancement achieved by the natural solubilizers was comparable to that obtained by the synthetic solubilizer polysorbate 80.In this respect, the enhancement due to the biles of both hen and fish was superior to that of the rabbit.

2-These findings would rationalize the use of such natural substances as promising additives for the development of optimal formulation conditions of poorly water soluble drugs.

Solubility study

Dissolution Study

Table 1. Surface tension of aqueous solutions of Aceclofenac solid dispersions prepared with different solubilizers at 25±0.5 o C Surface tension (mN) Solubilizer L/SDC SDCSLSTween 80 Rabbit bile Fish bile Hen bile concentration w/w%