Schizophrenia positive symptoms negative symptoms anx/dep aggressive symptoms cognitive symptoms 10-1 Stahl S M, Essential Psychopharmacology (2000)

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Presentation transcript:

schizophrenia positive symptoms negative symptoms anx/dep aggressive symptoms cognitive symptoms 10-1 Stahl S M, Essential Psychopharmacology (2000)

Positive Symptoms of Schizophrenia

Negative Symptoms of Schizophrenia

10-20 Stahl S M, Essential Psychopharmacology (2000) 100% 50% Age in years Functional Status

hypothalamus d c Nucleus accumbens Tegmentum b Substantia nigra Basal Ganglia a DOPAMINE PATHWAYS 10-7 Stahl S M, Essential Psychopharmacology (2000)

mesolimbic overactivity = positive symptoms of psychosis 10-9 Stahl S M, Essential Psychopharmacology (2000)

Mesolimbic Dopaminergic Hyperactivity in Schizophrenia Laruelle et al., Ann NY Acad Sci (2003)

Relationship Between Affinity for Dopamine D 2 Receptors and Daily Dose for Treating Schizophrenia

primary dopamine deficiency D2 receptor blockade secondary dopamine deficiency mesocortical pathway increase in negative symptoms Stahl S M, Essential Psychopharmacology (2000)

Hypofunction of Mesocortical Dopaminergic Transmission in Schizophrenia Laruelle et al., Ann NY Acad Sci (2003)

Dopamine Dyregulation in Schizophrenia

Glutamate-Dopamine Interactions in Schizophrenia Takahata and Moghaddam, J Neurochem (2000)

Kaplan and Hammer, Am Psychiatric Press Inc, 2002

Thesis- Dopamine Dysregulation in Schizophrenia Mechanism Schizophrenia Sxs 1. Hypoactivity of PFC Negative/Cognitive DA Systems Sxs 2. Hyperactivity of NAc Positive Sxs DA Systems 3. Neuroleptic induced Improves Positive Sxs DA blockade Worsens Negative Sxs