Clivus Chordoma Shirley H. Wray, M.D., Ph.D. Professor of Neurology, Harvard Medical School Director, Unit for Neurovisual Disorders Massachusetts General.

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Clivus Chordoma Shirley H. Wray, M.D., Ph.D. Professor of Neurology, Harvard Medical School Director, Unit for Neurovisual Disorders Massachusetts General Hospital

Neuroimaging Figure 1 - Axial CECT scan shows destructive central skull base lesion that expands the cavernous sinus and encases both internal carotid arteries.

Neuroimaging Figure 2 - Sagittal pre-contrast T1-weighted MR shows the lesion is mostly hypointense compared to brain. Note destruction of posterior clivus with extension to the pons.

Neuroimaging Figure 3 - Coronal T2WI shows the lesion is extremely hyperintense, characteristic of most chordomas. Note elevation and encasement of both carotid arteries.

Neuroimaging Figure 4 - Sagittal post-contrast T1-weighted MR shows the lesion enhances strongly but inhomogeneously.

Pathology chordoma.jpg Chordomas are characterized by cords of physaliferous cells with mucinous vacuoles. They often occur in the clival, sellar, and sphenoid regions and cause bony destruction.