LIPID METABOLISM

HYDROLYSIS

ADIPOSE TISSUE 90% of adipose tissue is tryglycerides It supplies energy. Insulation. Provides minor physical protection Cholestrol storage

GLYCEROL GLUCOSE PYRUVATE GLYCOLYSIS

FATTY ACIDS Activation of Fatty Acid

 -OXIDATION Blue box =  carbon Red box = acetyl CoA

 -OXIDATION 1.Activation by addition Coenzyme-A 2.  carbon oxidized from CH 2 to C=O (ketone) 3.Molecule split into acetyl CoA and Fatty acid 2 carbons shorter 4.Another Coenzyme-A added to shortened Fatty acid

Each cycle produces 1 acetyl-CoA –18 carbon fatty acid would give 9 acetyl-CoA Cycles required is # of carbons/2 – 1 –18 carbon fatty acid would require 8 cycles Amount of energy from Fatty Acid depends on length of carbon chain –18 carbon fatty acid would 120 ATP

LIPOGENESIS Making triglycerides from glycerol and fatty acids Anabolic process Fatty acids made linking 2 carbon acetyl groups (from acetyl CoA) to growing chain Most Fatty acids have an even number of carbons

ESSENTAIL FATTY ACIDS Those needed by the body, but not synthesized within the body in adequate amounts. Found in fish and some plants

GLUCOSE TRIGLYCERIDES PYRUVATE GLYCEROL ACETYL-CoA glycolysis gluconeogenesis  -oxidation lipogensis