PRPP synthetase Nucleoside phosphorylases Phosphoribosyl transferases.

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Presentation transcript:

PRPP synthetase Nucleoside phosphorylases Phosphoribosyl transferases

The committed step of de novo purine nucleotide biosynthesis

Phosphoribosylamine synthase: cooperativity with respect to PRPP concentration & product inhibition

Outline of de novo purine nucleotide biosynthesis

Outline of de novo pyrimidine nucleotide biosynthesis

Enzymes I. Ribonucleotide reductase II. Nucleotide diphosphate kinase III. dCMP kinase IV. dUTP diphosphohydrolase V. dCMP deaminase VI. Thymidylate synthase VII. FH 2 reductase