Enhancement of Dissolution and Release Rate of Piroxicam From Witepsol W35 Suppository Base Using Lyophilized Inclusion Adduct of Piroxicam With Skimmed.

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Enhancement of Dissolution and Release Rate of Piroxicam From Witepsol W35 Suppository Base Using Lyophilized Inclusion Adduct of Piroxicam With Skimmed Milk. M.M. Nafadi Department of pharmaceutics, Faculty of Pharmacy, Cairo University, Egypt.

Aim of work The objective of the present investigation was to formulate piroxicam IC and its PM with SM to improve its dissolution rate and consequently its anti-inflammatory efficiency. Different suppository bases were used, including witepsol W35 which is a hard fat but its characteristics were superior in safety and accelerated the drug release. The objective of the present investigation was to formulate piroxicam IC and its PM with SM to improve its dissolution rate and consequently its anti-inflammatory efficiency. Different suppository bases were used, including witepsol W35 which is a hard fat but its characteristics were superior in safety and accelerated the drug release.

Conclusion Conclusion the drug released from its IC adduct incorporated in witepsol W35 gave the highest release rate. Therefore, it would be possible to formulate piroxicam IC adduct having a small dose for rectal suppositories and oral administration to avoid gastrointestinal disturbance. the drug released from its IC adduct incorporated in witepsol W35 gave the highest release rate. Therefore, it would be possible to formulate piroxicam IC adduct having a small dose for rectal suppositories and oral administration to avoid gastrointestinal disturbance.

Table(1):Solubility of Piroxicam as a plain Drug, in IC and PM with SM in Distilled Water at 25 oC. Table(1):Solubility of Piroxicam as a plain Drug, in IC and PM with SM in Distilled Water at 25 oC. Solubility(%w/v) Drug Form Piroxicam (%w/v) 0.293IC PM Plain Drug 0.1

Time min Fig(5) : Dissolution Pattern of Piroxicam Powder, its IC and PM in Distilled water at 37C. Time min Fig(5) : Dissolution Pattern of Piroxicam Powder, its IC and PM in Distilled water at 37C.