Glutathione is an Antioxidant Glutathione peroxidase (GSH peroxidase) Glutathione reductase (GSSG reductase) ROOH NADH Glutathione (GSH) Glutathione disulfide.

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Presentation transcript:

Glutathione is an Antioxidant Glutathione peroxidase (GSH peroxidase) Glutathione reductase (GSSG reductase) ROOH NADH Glutathione (GSH) Glutathione disulfide (GSSG)

Glutathione is a Sulfur Nucleophile Involved in the Metabolism of Foreign Substances Glutathione S-transferases catalyze the conjugation of glutathione with foreign compounds and their metabolites. Conjugation reduces activity of xenobiotics and allows removal from body by increases polarity and water solubility. Glutathione (GSH): glutamic acid-cysteine-glycine tripeptide

Aflatoxin-B 1 Toxicity via DNA Alkylation Aflatoxin B1 Aspergillus flavus Fungus in contaminated nuts and grains DNA guanine residue Aflatoxin B1 epoxide Toxin bound to DNA Inhibition of DNA replication, RNA synthesis, mutagenesis

Glutathione Conjugation with Aflatoxin-B 1 Metabolite Allows its Removal From Body Aflatoxin B1 Glutathione Aflatoxin B1 epoxide Glutathione aflatoxin conjugate Detoxification, removal from body