Introduction to the Knowledge Discovery Department Institute for Infocomm Research Limsoon Wong Deputy Executive Director (Research) I 2 R: Imagination.

Slides:



Advertisements
Similar presentations
U.S. Food and Drug Administration Notice: Archived Document The content in this document is provided on the FDAs website for reference purposes only. It.
Advertisements

anywhere and everywhere. omnipresent A sensor network is an infrastructure comprised of sensing (measuring), computing, and communication elements.
Information Society Technologies Third Call for Proposals Norbert Brinkhoff-Button DG Information Society European Commission Key action III: Multmedia.
Regional Innovation Strategy RIS OF SOUTH MORAVIA & MASARYK UNIVERSITY Prof. Martin Bareš vice-rector of Masaryk University Petr Chládek RIS manager, JIC.
Senate Education Committee Briefing Russell Ingram, Executive Director March 23, 2011.
Prof. Carolina Ruiz Computer Science Department Bioinformatics and Computational Biology Program WPI WELCOME TO BCB4003/CS4803 BCB503/CS583 BIOLOGICAL.
Imagination to Reality Powers Up Dare-to-Dream Research Collaborations Limsoon Wong Institute for Infocomm Research.
Show & Tell Limsoon Wong KRDL Datamining: Turning Biological Data into Gold.
1 Computer Engineering Department College of Computer Sciences and Engineering Tuesday 18 November 2008 King Fahd University of Petroleum & Minerals.
EHealth Unit FP6 - 1st IST Call for Proposals 28/1/2003 The eHealth Strategic Objective Julian Ellis eHealth Unit, DG Information Society
Edward H. Shortliffe, MD, PhD College of Physicians & Surgeons
Introduction to the Knowledge Discovery Department Institute for Infocomm Research Limsoon Wong Deputy Executive Director (Research) I 2 R: Imagination.
Jeffery Loo NLM Associate Fellow ’03 – ’05 chemicalinformaticsforlibraries.
Centre for Health & Technology Maritta Perälä-Heape, PhD Director, CHT.
Computer and Information Sciences EDUCATION RESEARCH.
MS DB Proposal Scott Canaan B. Thomas Golisano College of Computing & Information Sciences.
Center for Biologics Evaluation and Research Applying Regulatory Science to Advance Development of Innovative, Safe and Effective Biologic Products Carolyn.
Bindley Bioscience Center Vision: Nurture interactive communication and interdisciplinary discovery with flexible laboratory project spaces and an open.
University of Kansas A KTEC Center of Excellence 1 Victor S. Frost Director, Information & Telecommunication Technology Center Dan F. Servey Distinguished.
University of Kansas A KTEC Center of Excellence 1 Victor S. Frost Director, Information & Telecommunication Technology Center Dan F. Servey Distinguished.
Center for Biologics Evaluation and Research FDA Overview Site Visit Carolyn A. Wilson, Ph.D. Associate Director for Research.
What is “Biomedical Informatics”?. Biomedical Informatics Biomedical informatics (BMI) is the interdisciplinary field that studies and pursues.
EHealth Challenges and Opportunities E-health: Multi-disciplinary of E (ICT) and Healthcare, or applied ICT in healthcare (Design oriented), or healthcare.
---- Mark Borodovsky a short intro Position open: Scientist - Pathway Informatics (June 2009) THE POSITION The successful candidate will join the Computational.
9/30/2004TCSS588A Isabelle Bichindaritz1 Introduction to Bioinformatics.
Informations Systems in Health Care Mapping out the terrain.
Research at Department of Computer and Systems Sciences – DSV.
FACULTY OF COMPUTER SCIENCE & INFORMATION TECHNOLOGY.
Institute of Systems Biology (INBIOSIS)/ School of Biosciences & Biotechnology (Faculty of Science & Technology), Bioinformatics Development in Malaysia.
Knowledge Discovery in Biomedicine Limsoon Wong Institute for Infocomm Research.
Copyright  2003 limsoon wong Data Mining of Gene Expression Profiles for the Diagnosis and Understanding of Diseases Limsoon Wong Institute for Infocomm.
EF on IST in FP6 in Greece Information Day Athens-Thessaloniki, December 2002 The IST Priority in FP6 Erastos Filos
Bioinformatics and medicine: Are we meeting the challenge?
Master’s programme Game and Media Technology. 10/1/20152 General Information:  Gaming and multimedia are booming industry  Increased use of gaming as.
CONTENTS Sending and receiving devices Mobile devices connected to networks – Smart phones – Personal digital assistants – Hand-held computers – Netbook.
Olga E. SegouDr. Stelios C.A. Thomopoulos Integrated Systems.
Integrated Biomedical Information for Better Health Workprogramme Call 4 IST Conference- Networking Session.
CSL Global Infotech Prof Chong Tow Chong Executive Director Science & Engineering Research Council Agency for Science, Technology and Research (A*STAR)
Text Mining Special Interest Group Stuart Murray, Wyeth Research Novartis Institute for Biomedical Research, Cambridge, MA 6-8 th October 2004.
DOE 2000, March 8, 1999 The IT 2 Initiative and NSF Stephen Elbert program director NSF/CISE/ACIR/PACI.
Knowledge Discovery from Biological and Clinical Data: BASIC BACKGROUND.
Agent-based methods for translational cancer multilevel modelling Sylvia Nagl PhD Cancer Systems Science & Biomedical Informatics UCL Cancer Institute.
Center for Biologics Evaluation and Research Carolyn A. Wilson, Ph.D. Associate Director for Research Applying Regulatory Science to Advance Development.
FOREWORD By: Howard Shrobe MIT CS & AI Laboratory
An R&D Manager’s Perspective TechExpo October 5, 2004 Presented by: Veena Rawat.
Copyright  2003 limsoon wong From Informatics to Bioinformatics: The Knowledge Discovery Perspective Limsoon Wong Institute for Infocomm Research Singapore.
Catawba County Board of Commissioners Retreat June 11, 2007 It is a great time to be an innovator 2007 Technology Strategic Plan *
Biological Signal Detection for Protein Function Prediction Investigators: Yang Dai Prime Grant Support: NSF Problem Statement and Motivation Technical.
DIALing the IBIVU Vrije Universiteit Amsterdam Jaap Heringa Centre for Integrative Bioinformatics VU (IBIVU) Faculty of Sciences / Faculty of Earth and.
Limsoon Wong Laboratories for Information Technology Singapore From Informatics to Bioinformatics.
Components of wireless LAN & Its connection to the Internet
OMICS International welcomes submissions that are original and technically so as to serve both the developing world and developed countries in the best.
Trend in diagnostic biochip development Eiichiro Ichiishi, M.D., Ph.D. Department of Internal Medicine International University of Health and Welfare Hospital.
1 Bioinformatics at Norwegian University of Science and Technology Professor Finn Drabløs Department of Cancer Research and Molecular Medicine Finn Drabløs.
OMICS International welcomes submissions that are original and technically so as to serve both the developing world and developed countries in the best.
Internet of Things. IoT Novel paradigm – Rapidly gaining ground in the wireless scenario Basic idea – Pervasive presence around us a variety of things.
Research Institute on Communications. Research Institute on Communications (1) Provide an environment for research into the issues necessary to support.
NCP Info DAY, Brussels, 23 June 2010 NCP Information Day: ICT WP Call 7 - Objective 1.3 Internet-connected Objects Alain Jaume, Deputy Head of Unit.
Limsoon Wong Laboratories for Information Technology Singapore From Datamining to Bioinformatics.
Tools in Bioinformatics Ontologies and pathways. Why are ontologies needed? A free text is the best way to describe what a protein does to a human reader.
UNIVERSITY OF JYVÄSKYLÄ FACULTY OF INFORMATION TECHNOLOGY IT with a human touch 2010.
Center for Bioinformatics and Genomic Systems Engineering Bioinformatics, Computational and Systems Biology Research in Life Science and Agriculture.
BioMedical Cluster New opportunities for innovators and investors with Bio-Medical Cluster of Skolkovo Foundation Innovation in Medical Technologies Conference,
Show & Tell Limsoon Wong Kent Ridge Digital Labs Singapore Role of Bioinformatics in the Genomic Era.
Welcome to Informatics
Future Technologies FTC 2016 Future Technologies Conference December 2016 San Francisco, United States.
Data Warehousing and Data Mining
What is “Biomedical Informatics”?
Genes to Function to Therapeutics
Bringing Open Science to The Montreal Neurological Institute
Presentation transcript:

Introduction to the Knowledge Discovery Department Institute for Infocomm Research Limsoon Wong Deputy Executive Director (Research) I 2 R: Imagination to reality

I 2 R Knowledge Discovery Dept: INTRODUCTION

I2RI2R mission: Advance Infocomm Technology to benefit humanity and create prosperity for S’pore core values: Dedication to excellence, passion for innovation, integrity & respect size: 350 RSEs SERCBMRC IHPC DSI IMRE SIMTECH IME ICES

EDB-iDA ICT Cluster Map

Next Gen IP End-to-end QoS Mobile Middleware Mobile Adhoc Networks Mobile Sensor Networks Organization I2RI2R Communications & DevicesServices & ApplicationsMedia Processing Human Computer Interaction Media Semantics Infocomm Security E-Service Infrastructure Knowledge Discovery Radio SystemsNetworkingLightwaveEmbedded Systems Digital Wireless Mutimedia Signal Processing Noise Reduction Media Adaptation Mixed Media Mining Natural Language Synergy Pervasive Media Perceptual Human Media Speech & Dialogue Biometrics Cryptography Network security Information security Service Composition Service creation Data-in-Network Connected Home Secure Filesystem/ DBMS Modem Technology Multiple Access Smart Antenna Array Systems Network Design WDM Systems Fibre Technology Terminal Software Defined Radio Transceiver system Antenna Radio Over Fiber UWB Knowledge Extraction Decision Systems Discovery Systems

Information Security E-services Infrastructure Knowledge Discovery Services & Applications Knowledge Extraction Data fusion from sensors, knowledge extraction technologies. Applications in functional genomics & gene regulatory networks Decision Systems Data Mining technologies. Applications in clinical data analysis and protein network analysis Discovery Systems Data cleansing, modeling & knowledge management technologies. Applications in immunoinformatics and venominformatics Service Creation Policy-based framework for creating/managing application, storage and network services Data-in-Network High-speed data cache and IPC on optical network Service Composition Tech for consumers to create personalized services from component e- services Connected Home Reference design for an OSGi compliant residential gateway Cryptography Cryptographic techniques for privacy protection, high- speed encryption, group digital signatures and new public key infrastructure Information Security Techniques for privacy protection, peer-to-peer system security and media security Network Security Wireless network security, intrusion detection and technology to trace attackers Secure Filesystem Steganographic and reliable file systems/DBMSs on externally managed platforms

Integration Technology (Kleisli) Cleansing & Warehousing (FIMM) MHC-Peptide Binding (PREDICT) Protein Interactions Extraction (PIES) Gene Expression & Medical Record Datamining (PCL) Gene Feature Recognition (Dragon) Venom Informatics years of bioinformatics R&D in Singapore ISS KRDL LIT/I 2 R GeneticXchange Molecular Connections Biobase History

Objectives –Translate inspiration from biological systems into advancement of life and computing sciences –Advance data mining technologies in decision systems for complex problems Direction & Plan To work on practical systems for –data mining –data cleansing –knowledge extraction Applied to –gene regulation –protein interaction –clinical data analysis –ligand-receptor interaction in addition to non-bio areas

I 2 R Knowledge Discovery Dept: RECENT ACCOMPLISHMENTS

Predict Epitopes, Find Vaccine Targets Vaccines are often the only solution for viral diseases Finding & developing effective vaccine targets (epitopes) is slow and expensive process Develop systems to recognize protein peptides that bind MHC molecules Develop systems to recognize hot spots in viral antigens

Recognize Functional Sites, Help Scientists Effective recognition of initiation, control, and termination of biological processes is crucial to speeding up and focusing scientific experiments Data mining of bio seqs to find rules for recognizing & understanding functional sites Dragon’s 10x reduction of TSS recognition false positives

Diagnose Leukaemia, Benefit Children Childhood leukaemia is a heterogeneous disease Treatment is based on subtype 3 different tests and 4 different experts are needed for diagnosis  Curable in USA,  fatal in Indonesia A single platform diagnosis based on gene expression Data mining to discover rules that are easy for doctors to understand Cancer Cell, 1: , 2002

Understand Proteins, Fight Diseases Understanding function and role of protein needs organised info on interaction pathways Such info are often reported in scientific paper but are seldom found in structured databases Knowledge extraction system to process free text extract protein names extract interactions

FANTOM2 Consortium Nature 420, , 2002 Recent Collaborations/Partners Molecular Connections, India RIKEN, Japan St Jude, USA BioBase, Germany Canberra Hosp., Australia GIS, Singapore

I 2 R Knowledge Discovery Dept: PEOPLE

18 full-time staff comprising 9 PhD, 6MSc, and 3BSc Our faculty holds adjunct professorial positions in SANBI, Univ. of Canberra, NUS, and NTU Who will you be working with... Limsoon WongSee-Kiong Ng Jinyan LiVladimir Bajic Vladimir Brusic Other PIs Heads of labs

Track Record Journals: 3 chief editorial roles, and 9 editorial board memberships International Conferences (last 5 years): 4 conference chairs, and more than 40 program committee roles, 10 keynote lectures, and dozens of plenary talks Publications (last 5 years): More than 100 in last 5 years, mostly in reputable journals (e.g. Nature, PNAS, Cancer Cell, JACM) and top conferences. Patents (last 5 years): 1 granted and 6 pending Commercialization (last 5 years): 2 international start-ups and one software licensed