Recombination Early Experiments: 1947 Alfred Hershey and Max Delbrück 1961 Matthew Meselson and Jean Weigle *Homologous Genetic Recombination *Site Specific.

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Presentation transcript:

Recombination Early Experiments: 1947 Alfred Hershey and Max Delbrück 1961 Matthew Meselson and Jean Weigle *Homologous Genetic Recombination *Site Specific Recombination *Transposition

Homologous Recombination *Two broad categories (pathways):

Homologous Recombination

RecBCD Pathway

RecBCD Pathway RecA filament

RecA at work

RuvAB facilitate branch migration

Gene Targeting in Embryonic Stem Cells

Gene Targeting in Embryonic Stem Cells

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