Evaluation of CN iron in Huntington’s Disease using Susceptibility Weighted Imaging Lakshman Gollapalli.

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Presentation transcript:

Evaluation of CN iron in Huntington’s Disease using Susceptibility Weighted Imaging Lakshman Gollapalli

Huntington’s Disease (HD) Huntington’s disease is a dominantly inherited degenerative disease of the CNS The pathological features include atrophy of the CN, chorea and neuronal loss Changes in caudate volume have been documented in MRI studies

Susceptibility Weighted Imaging (SWI) SWI exploits the magnetic susceptibility effects generated by local field inhomogeneities Signals from tissues with different susceptibilities compared to their neighboring tissue will become out of phase New type of contrast

Results

Using SWI for noninvasive tracking of SVZ labeled cells in Rat subjected to stroke SVZ cells labeled with iron particles were injected in Rat subjected to stroke Using SWI as a means to track the cell migration and identify angiogenesis