This article and any supplementary material should be cited as follows: Mohajeri-Tehrani MR, Nasiripoor F, Torkaman G, Hedayati M, Annabestani Z, Asadi.

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This article and any supplementary material should be cited as follows: Mohajeri-Tehrani MR, Nasiripoor F, Torkaman G, Hedayati M, Annabestani Z, Asadi MR. Effect of low-intensity direct current on expression of vascular endothelial growth factor and nitric oxide in diabetic foot ulcers. J Rehabil Res Dev. 2014;51(5):815–24. Slideshow Project DOI: /JRRD JSP Effect of low-intensity direct current on expression of vascular endothelial growth factor and nitric oxide in diabetic foot ulcers Mohammad Reza Mohajeri-Tehrani, MD; Faezeh Nasiripoor, MSc; Giti Torkaman, PhD; Mehdi Hedayati, PhD; Zohreh Annabestani, MD; Mohammad Reza Asadi, MSc

This article and any supplementary material should be cited as follows: Mohajeri-Tehrani MR, Nasiripoor F, Torkaman G, Hedayati M, Annabestani Z, Asadi MR. Effect of low-intensity direct current on expression of vascular endothelial growth factor and nitric oxide in diabetic foot ulcers. J Rehabil Res Dev. 2014;51(5):815–24. Slideshow Project DOI: /JRRD JSP Aim – Investigate effect of low-intensity cathodal direct current on release of plasma vascular endothelial growth factor (VEGF) and nitric oxide (NO) in diabetic foot ulceration. Relevance – Diabetic foot ulceration is a significant complication of diabetes. – Evidence exists that expression of growth factors like VEGF may reduce its occurrence.

This article and any supplementary material should be cited as follows: Mohajeri-Tehrani MR, Nasiripoor F, Torkaman G, Hedayati M, Annabestani Z, Asadi MR. Effect of low-intensity direct current on expression of vascular endothelial growth factor and nitric oxide in diabetic foot ulcers. J Rehabil Res Dev. 2014;51(5):815–24. Slideshow Project DOI: /JRRD JSP Method Subjects: – 20 type 2 diabetic patients with foot ulceration. – 13 age-matched healthy subjects. Treatment (random assignment): – Electrical stimulation (ES) (n = 10). Cathodal direct current 1 h/d, 3 d/wk for 4 wk (12 sessions). – Sham ES (placebo, n = 10). Measures: – VEGF and NO (blood samples) at 1 st and 12 th sessions before and after intervention. – Wound surface area and skin temperature at 1 st, 6 th, and 12 th sessions.

This article and any supplementary material should be cited as follows: Mohajeri-Tehrani MR, Nasiripoor F, Torkaman G, Hedayati M, Annabestani Z, Asadi MR. Effect of low-intensity direct current on expression of vascular endothelial growth factor and nitric oxide in diabetic foot ulcers. J Rehabil Res Dev. 2014;51(5):815–24. Slideshow Project DOI: /JRRD JSP Results VEGF: – Significantly increased in ES compared with sham ES after 1st and 12th sessions. NO: – Significantly increased in ES compared with sham ES after 12th session. Skin temperature: – Significantly higher increase in ES than sham ES.

This article and any supplementary material should be cited as follows: Mohajeri-Tehrani MR, Nasiripoor F, Torkaman G, Hedayati M, Annabestani Z, Asadi MR. Effect of low-intensity direct current on expression of vascular endothelial growth factor and nitric oxide in diabetic foot ulcers. J Rehabil Res Dev. 2014;51(5):815–24. Slideshow Project DOI: /JRRD JSP Conclusion Application of low-intensity ES increases VEGF and NO expression – May lead to improved blood flow and tissue temperature and, consequently, wound healing in diabetic foot ulceration.