Pedigree charts Pedigree notes handout. What is a pedigree? A pedigree is a family tree that shows how a trait is passed from generation to generation.

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Presentation transcript:

Pedigree charts Pedigree notes handout

What is a pedigree? A pedigree is a family tree that shows how a trait is passed from generation to generation

Some Pedigree Symbols - person being studied - individuals having a common ancestor

1. Squares indicate MALES There are 7 males in this pedigree!

3. Circles indicate FeMALES There are 7 females in this pedigree!

5. Shaded Shapes Represent Individuals that have the trait There are 2 individuals in this pedigree that are affected!

6. Matings Between Individuals = Horizontal lines

Pedigrees! 7. How many generations are shown here? 3!

Vertical line from relationship line = children

8. How many children do parents in generation 1 have? 3 children!

9. How many of the children in generation 3 have the trait? One!

1. Pedigree 2 1. How many people in the family have the trait? 7 people

Pedigree 2 2. What is the sex of individual I – 1? 3. Does individual I-1 have the trait? Male YES

Pedigree 2 4. List the individuals in generation III that have the trait. III-1, III-6, III-8

Pedigree 2 5. How many children did the couple from generation 1 have? 5 children

Pedigree 2 6. What is the relationship between individual II-8 and III-9? Mother- Daughter

Pedigrees are most useful when analyzing a family’s history of genetic diseases and traits. We can also predict if future family members will inherit a disease or trait using a pedigree. Let’s look at some examples Pedigrees and Traits

Example 1: The pedigree below shows the inheritance of handedness in humans over three generations. The allele for right-handedness (R) is dominant over left-handedness (r). The shaded individuals below are recessive for handedness R = right- handed r = left handed

How many generations are there? 2. How many individuals are left handed? 3. Which individuals in the third generation are right handed? 3 4 III-1 and III-3

4. What is the genotype and phenotype of individual I-2 Genotype Phenotype 5. If the father (I-1) is heterozygous, what is the genotype of his two children? II -1 ____________II – 3 ___________ rr Rr rr Left-hand

Example 2: Huntington’s Disease (H) is a dominant disorder. 1. What is the relationship between individual III-1 and III-2 Brother and sister

2. What is the relationship between individual II-3 and III-4 Aunt-nephew Example 2

3. How many individuals in generation II do not have Huntington’s disease? 3 people (not shaded)

4. Based on the traits of IV-5, IV-6, and IV-7, what MUST the genotype of III-8 be? Hh (Heterozygous)

Genotype of IV-7: Heterozygous genotype: 5. If individual IV-7 mated with a heterozygous individual, what is the percentage their offspring has Huntington’s? hh Hh

Hhhh 50% has the disease h H

**Note on sex-linked pedigrees For sex-linked traits, female carriers are always represented as a circle half-way shaded, even though they do not express the recessive trait. A female carrier looks like: