5.1 How Is the Structure of the Cell Membrane Related to Its Function? All the membranes of a cell have a similar basic structure Proteins suspended in a double layer of phospholipids Phospholipids are responsible for the isolating function of membranes Proteins are responsible for selectively exchanging substances and communicating with the environment, controlling biochemical reactions, and forming attachments

5.1 How Is the Structure of the Cell Membrane Related to Its Function? Functions of the plasma membrane It isolates the cell’s contents from the external environment It regulates the exchange of essential substances It allows communication between cells It creates attachments within and between cells It regulates biochemical reactions

5.1 How Is the Structure of the Cell Membrane Related to Its Function? Membranes are “fluid mosaics” in which proteins move within layers of lipids The “fluid mosaic” model of a membrane was proposed in 1972 by S.J. Singer and G.L. Nicolson This model indicates that each membrane consists of a mosaic, or “patchwork,” of different proteins that constantly shift and flow within a viscous fluid formed by a double layer of phospholipids A fluid is any substance whose molecules can flow past one another and includes gases, liquids, and cell membranes

Figure 5-1 The plasma membrane interstitial fluid (outside) carbohydrate protein extra- cellular matrix glycoprotein receptor protein phospholipid bilayer binding site phospholipid transport protein connection protein pore cholesterol recognition protein enzyme cytoskeleton cytosol (fluid inside cell) 4

5.1 How Is the Structure of the Cell Membrane Related to Its Function? The fluid phospholipid bilayer helps to isolate the cell’s contents Phospholipids are the basis of membrane structure and consist of two very different parts A polar, hydrophilic head Two nonpolar, hydrophobic tails The outer surfaces of animal plasma membranes are bathed in watery interstitial fluid, a weakly salty liquid resembling blood without its cells or proteins

Figure 5-2 A phospholipid tails (hydrophobic) head (hydrophilic) 6

5.1 How Is the Structure of the Cell Membrane Related to Its Function? The fluid phospholipid bilayer helps to isolate the cell’s contents (continued) The phospholipid bilayer is the fluid portion of the membrane Plasma membranes face both exterior and interior watery environments

5.1 How Is the Structure of the Cell Membrane Related to Its Function? The fluid phospholipid bilayer helps to isolate the cell’s contents (continued) Hydrophobic and hydrophilic interactions drive phospholipids into bilayers Hydrogen bonds between water and the hydrophilic heads cause the heads of the outer layer to orient outward toward the watery exterior, while the heads of the inner layer face the watery interior The nonpolar tails, being hydrophobic, face the inside of the membrane, away from the watery environment around the bilayer

Animation: Plasma Membrane Structure

Figure 5-3 The phospholipid bilayer of the cell membrane interstitial fluid (watery environment) phospholipid hydrophilic head hydrophobic tails bilayer hydrophilic head cytosol (watery environment) 10

5.1 How Is the Structure of the Cell Membrane Related to Its Function? The fluid phospholipid bilayer helps to isolate the cell’s contents (continued) The phospholipid bilayer’s flexible, fluid membrane allows for cellular shape changes Individual phospholipid molecules are not bonded to one another Some of the phospholipids have unsaturated fatty acids, whose double bonds introduce “kinks” into their “tails” The above features make the membrane fluid

Figure E5-1 Tail kinks in phospholipids increase membrane fluidity more unsaturated greater fluidity more saturated less fluidity 12

5.1 How Is the Structure of the Cell Membrane Related to Its Function? The fluid phospholipid bilayer helps to isolate the cell’s contents (continued) Water-soluble substances such as salts, amino acids, and sugars cannot easily cross phospholipid bilayers However, the isolation provided by the plasma membrane is not complete, and very small molecules such as water, oxygen, and carbon dioxide as well as larger, lipid-soluble molecules can pass through this selective barrier

5.1 How Is the Structure of the Cell Membrane Related to Its Function? The fluid phospholipid bilayer helps to isolate the cell’s contents (continued) Membranes become more fluid at high temperatures (more movement) and less fluid at low temperatures (less movement) Cell membranes of organisms living in low temperatures tend to be more unsaturated (more kinks help them maintain fluidity) Cholesterol stabilizes membranes, affecting fluidity and reducing permeability

5.1 How Is the Structure of the Cell Membrane Related to Its Function? A variety of proteins form a mosaic within the membrane Proteins are embedded within, or attached to, the phospholipid bilayer Many proteins have attached carbohydrates (glycoproteins) on their outer membrane surface

5.1 How Is the Structure of the Cell Membrane Related to Its Function? A variety of proteins form a mosaic within the membrane (continued) Membrane proteins may be grouped into five major categories Enzymes Recognition proteins Receptor proteins Connection proteins Transport proteins

5.1 How Is the Structure of the Cell Membrane Related to Its Function? A variety of proteins form a mosaic within the membrane (continued) Enzymes are proteins that promote chemical reactions that synthesize or break apart biological molecules Some plasma membrane enzymes are used to synthesize the extracellular matrix, a web of protein and glycoprotein fibers that fills spaces between animal cells

5.1 How Is the Structure of the Cell Membrane Related to Its Function? A variety of proteins form a mosaic within the membrane (continued) Receptor proteins trigger cellular responses upon binding of specific molecules, such as hormones, sent by other cells Recognition proteins are glycoproteins that serve as identification tags on the surface of a cell

Figure 5-4 Receptor protein activation (interstitial fluid) A messenger molecule binds to the receptor protein messenger molecule receptor protein Messenger molecule binding activates the receptor protein, changing its shape The activated receptor protein stimulates a response in the cell (cytosol) 19

5.1 How Is the Structure of the Cell Membrane Related to Its Function? A variety of proteins form a mosaic within the membrane (continued) Connection proteins anchor cell membranes in various ways Maintain cell shape by linking the plasma membrane to the cell’s cytoskeleton Link the cytoskeleton inside the cell with the extracellular matrix outside, anchoring the cell in place within a tissue Form connections between adjacent cells

5.1 How Is the Structure of the Cell Membrane Related to Its Function? A variety of proteins form a mosaic within the membrane (continued) Transport proteins regulate the movement of hydrophilic molecules through the plasma membrane Channel proteins are pores that can be opened or closed to allow specific substances to pass across the membrane Carrier proteins bind substances and carry them through the membrane, sometimes using cellular energy