TABLETS a mixture of powders compacted to form a single, rigid body most common dosage form possess a number of advantages B. AmsdenCHEE 440

Types intended for release into GIT  compressed tablets  multiple compressed tablets effervescents chewable buccal or sublingual vaginal coated tablets  polymer film, gelatin extended release immediate release B. AmsdenCHEE 440

Desired Properties contains stated amount of drug able to withstand stresses of manufacture, transport and handling provides desired bioavailability acceptable to patient B. AmsdenCHEE 440

Drug Release B. AmsdenCHEE 440

Tabletting Process Basics  powders fed into a die  powder compressed between punches  tablet ejected from die B. AmsdenCHEE 440

Machinery rotary tablet press B. AmsdenCHEE 440

Tablet Components drug (5-10%) fillers (80%) binders disintegrants antifrictional agents  antiadherents, glidants, lubricants miscellaneous B. AmsdenCHEE 440

Tabletting Powder Properties  free flowing particles  cohesion of particles upon compaction  compacted particles must not adhere to punches and die 3 tabletting methods  wet granulation  dry granulation  direct compression B. AmsdenCHEE 440

Powder flow important to obtain uniform flow affected by particle properties  adhesion  cohesion  size  shape  density B. AmsdenCHEE 440

Powders packing geometry  shifting under vibration  affected by size and size distribution B. AmsdenCHEE 440

Powders flow affected by hopper design How to improve hopper flow? B. AmsdenCHEE 440

Wet Granulation B. AmsdenCHEE 440

Dry Granulation B. AmsdenCHEE 440

Direct Compression B. AmsdenCHEE 440