Nature Creates – We Refine Nature creates – we refine

Nature Creates – We Refine Feed enzyme development Enzymes for poultry and piglets feeds in Finland Biological silage preservatives International business activities, silage preservatives Export of Progut 1980’ies Suomen Rehu has long experience from functional feed ingredients Special feeds for better rumen function International business activities, enzymes Export to Scandinavia, Baltic countries, Russia, Taiwan Development of antibiotic replacement in piglet feeds Progut yeast hydrolysate Progut Rumen Progres Expansion of product range and export areas

Nature Creates – We Refine Drivers and targets for feed and ingredient development Production performance Animal health and wellbeing Food quality and safety Environment Feeding costs Antimicrobial resistance Animal welfare Production structure and disease challenge ”Animal health and productivity starts in the gut” ”Utilization of industry side-streams”

Nature Creates – We Refine Screening tube research model Product with desired functional properties Animal models and clinical trials Simulators Test tubes Compounds from industry side-streams Purpose, potential functions Availability, high volume, low price Development of new methods

Nature Creates – We Refine Development of Progut® and Progres® Rat trials, performance and challenge trials Simu- lators Bacterial growth inhibition and attachment assays Compounds to prevent E.coli growth and stimulate immunity Blood, larch tree extract Peat Brewery yeast waste Prevention of weaning diarrhea Prevention of Gram+ pathogens Compounds to prevent Gram + growth and improve feed efficiency Bark, knot-wood, tall oil other forest industry side streams

Nature Creates – We Refine A naturally occurring product from coniferous forests which is extracted as a by-product of the pulp manufacturing industry. The final refined product contains modified tall oil fatty acids and standardized amount of resin acids. We have develop this by-product into a specific concentration of resin acids and tall oil fatty acids which have never before been used in animal feeds Potential – To improve efficiency of meat production systems – To reduce reliance on antibiotics Patent protected product and applications.

Nature Creates – We Refine Market Need Global meat production will need to double by 2050 to cater for a rising population (FAO). Need for improved feed efficiency and environmental sustainability As production systems intensify, so does the pressure from pathogenic bacteria. Reliance on antibiotic solutions is unsustainable. Demand for effective natural solutions. The global feed additive market for natural additives is currently €3bn and rising. The need of antibiotic free meat production is consumer driven. “Antimicrobial resistance is one of our most serious health threats” The Lancet 2013 “ Half of the raw chicken meat carried antibiotic-resistant “superbug” bacteria in USA” Reuters

Nature Creates – We Refine Rosin, containing resin acids, has been used in traditional medicine in Finland for centuries The antimicrobial and antiprotozoal effects of resin acids are proven by scientific trials (Ali et al. 2012, Sipponen A. 2013) We are the first to develop the resin acids into a form that optimizes their efficacy in animal feeding (patents) 1. Naturally

Nature Creates – We Refine 2 Active: ProgRes supports the health and productivity of animals In trials Progres has: Prevented the growth of pathogenic Gram + bacteria –Such as clostridium perfringens and streptococcus suis Reduced the development of necrotis enteritis Modified the composition of intestinal microflora to beneficial direction Lead to decreased mortality, better health and growth performance in broilers and turkeys

Nature Creates – We Refine The effect of ProgRes on the growth of different pathogenic Gram+ bacteria (Alimetrics 2014)

Nature Creates – We Refine NE challenge trial with broiler chicks Alimetrics 2012 Wheat –based starter diet without coccidiostat Progres inclusion at 0, 0.1, 0.5, 1 and 3 kg/tn 1-day-old Male Ross 508 broiler chickens 6 chickens/pen, 8 pens/diet

Nature Creates – We Refine Progres® at high dose decreased mortality due to necrotis enteritis Alimetrics 2012 **, p < 0.01 (H. Kettunen et al J. Applied Animal Sci)

Nature Creates – We Refine Challenge trial in broilers at Schothorst Feed Research male broilers per treatment (6 *16 birds) Eimeria maxima challenge at day 9, Clostridium perfringens challenge at day 14 Progres additions 0, 1, 2 and 3 kg per ton The challenge caused a sub-clinical infection without affecting mortality

Nature Creates – We Refine Broiler trial at Schothorst Feed Research 2014 a,b p < 0.05

Nature Creates – We Refine Scientifically proven efficacy Improves performance Scientifically proven efficacy Improves performance

Nature Creates – We Refine Progres ® Trials in broilers 2014 CC + feedsDifference in end weight to the control g Difference in FCR, g France UK Denmark The Netherlands CC – feeds France The Netherlands Finland

Nature Creates – We Refine Other potential applications Trials with calves, piglets, fish and ruminants are going on Other feed applications (other poultry species, rabbits, sheep, pets etc.) Non-feed applications

Nature Creates – We Refine Thank you for your interest!