OPTIMISING MEDICINES DEVELOPMENT

Slides:



Advertisements
Similar presentations
HOW DO DRUGS GET INTO THE BODY?. WHY BE CONCERNED ABOUT HOW DRUGS GET INTO BODY? Bioavailability - % of dose that gets into body Bioequivalence - similarity.
Advertisements

Module 1-b Biological Barriers. DRUG PROBE DRUG PROBE Biological Barriers External barriers En route barriers Cellular barriers SkinMucosa BloodExtracellular.
Carl B. Goodman, Ph.D. Professor Pharmacology College of Pharmacy & Pharmaceutical Sciences Florida A&M University 308E FSH-SRC
Nanotechnology in Drug Discovery- Development and Delivery
Dr. Amira Taman, Ph.D. 1. Research in nanotechnology is rapidly progressing the development of new modalities for early diagnosis and medical treatment.
Nanotechnology in Drug Delivery for Cancer Current Technologies
Pharmaceutics 2 & 3 صيدلانيات 2&3 Unit / second semester Transdermal drug delivery system.
Overview  Founded in 2008  Privately held technology development company  Reorganized under new ownership as Tamarisk Technologies Group in 2014 About.
ABSORPTION OF DRUGS DR.SOBAN SADIQ.
Drug Formulation / Drug Delivery Raj Suryanarayanan (Sury) Department of Pharmaceutics College of Pharmacy 1.
Pharmacokinetics Chapter 4.
Drug-Like Properties: Optimizing Pharmacokinetics and Safety During Drug Discovery Li Di and Edward H. Kerns ACS Short Course.
N ANOPARTICLES IN BIOLOGY AND MEDICINE Antti Rautiainen KE Nanopartikkelit.
Page Break 2 + Strap line. About Quay Pharma Provider of contract development and manufacturing services to the pharmaceutical and healthcare industries.
Drug discovery and development
Drug Absorption Lesson 4. Drug T A Blood Brain CTZCTZ Organs & Tissues.
ERT 420 BIOPHARMACEUTICAL ENGINEERING ERT 420 BIOPHARMACEUTICAL ENGINEERING Semester 1 Academic Session 2012/2013 HUZAIRY HASSAN School Of Bioprocess Engineering.
PHARMACEUTICAL INDUSTRY Drug Discovery - natural sources, synthesis/modification Preclinical Studies biological properties - pharmacology, pharmacokinetics.
The Pharmaceutical Composition Methodology described in this presentation has been developed to improve controlled drug delivery through site specific.
Mosby items and derived items © 2007 by Mosby, Inc., an affiliate of Elsevier Inc. Chapter 2 Drug Action and Handling.
School of Pharmacy PHARMACEUTICS RESEARCH AREAS. PHARMACEUTICS SYMMETRY/SYNERGY Pre-formulation/Formulation Quality ControlDrug Delivery.
Pharmacology Department
MECHANISMS OF DRUG PERMEATION / TRANSPORT
Is the passage of drug from its site of administration to its site of action through cell membranes. Sites of Administration Sites of action Cell membrane.
PHARMACEUTICS- IV (PHT 414 ) Dr. Shahid Jamil SALMAN BIN ABDUL AZIZ UNIVERSITY COLLEGE OF PHARMACY L /9/2015 Factors Affecting Drug Absorption (Dosage.
Concepts and Applications of Pharmacokinetics
October 22, EFFECT OF PHYSICO- CHEMICAL PROPERTIES OF DRUG ON ABSORPTION By Dr. A. S. Adebayo.
Liposomes Dr. Aws Alshamsan Department of Pharmaceutics Office: AA87 Tel:
Formulation factors By Dr. A. S. Adebayo.
Absorption, Distribution, Metabolism and Elimination (ADME)
Tutorial 1 January 18, 2013.
Membranes Used in Drug Delivery Walter Trachim BMCB6583/2/12.
1 Abu Alam Ph.D. Advisory Committee for Pharmaceutical Science and Clinical Pharmacology July 23, 2008.
CHEE 4401 Definitions drug - any substance that affects the structure or functioning of an organism pharmaceutics - the area of study concerned with the.
The Pharmaceutical Composition Methodology described in this presentation has been developed to improve controlled drug delivery through site specific.
Dr. Muslim Suardi, MSi., Apt. Faculty of Pharmacy University of Andalas.
Lipophilicity & Permeability 김연수. Chapter 5. Lipophilicity.
Pharmacology Department
Introduction What is a Biowaiver?
Pharmacology Department
DRUG ABSORPTION AND DISTRIBUTION OF DRUG
CHEE 4401 Pathway of Absorption blood endothelium epithelium connective tissue, muscle.
Drug Absorption Lecture 4. Absorption n Movement from administration site into circulatory system n Complete when... l concentration at target equals.
김소연 Permeability OverviewPermeability FundamentalsPermeability EffectPermeability Structure Modification StrategiesProblem.
What is a Liposome? A liposome is a tiny bubble (vesicle), made out of the same material as a cell membrane. Liposomes can be filled with drugs, and used.
Gene therapy Lecture 8. What is a liposome? ◦ Spherical vesicles with a phospholipid bilayer Hydrophilic Hydrophobic.
Nanotechnology in Medicine Krešimir Pavelić, Marijeta Kralj and Damir Kralj Division of Molecular Medicine and Division of Material Chemistry Ruđer.
1/20 PRESENTED BY BRAHMABHATT BANSARI K. M. PHARM DEPARTMENT OF PHARMACEUTICS AND PHARMACEUTICAL TECHNOLGY L. M. COLLEGE OF PHARMACY.
By : Dr. Roshini Murugupillai
Pharmacokienetic Principles (2): Distribution of Drugs
Basic Principles: PK By: Alaina Darby.
Laboratoire d'Automatique et de Génie des Procédés
- Pharmaceutical Equivalence Study
The Biopharmaceutical Classification System (BCS)
Pharmacology I BMS 242 Lecture II (Continued)
Introduction What is a Biowaiver?
Introduction of Biopharmaceutics & Pharmacokinetics
Can Drug Discovery Research be Done At An Undergraduate Institution?
Gastrointestinal Absorption: Role of the Dosage Form
BTP 3822 BIOPHARMACEUTICS Quiz I
Biopharmaceutic Considerations in Drug Product Design
Pharmaceutics 2.
Pharmacology I BMS 242 Lecture II (Continued)
Factors Affecting Drug Absorption (Dosage form factor)
Pharmaceutical Technology I
Pharmacologic Principles – Chapter 2
Pharmacokinetics: Drug Absorption
Biopharmaceutics 4th year
Pharmacokinetics: Drug Absorption
Formulation factors By Dr. A. S. Adebayo.
Presentation transcript:

OPTIMISING MEDICINES DEVELOPMENT DR KHULOUD T. AL-JAMAL Institute of Pharmaceutical Science King’s College London

Learning outcomes Discovery of new and better medicines Describe the problems commonly associated with making medicines and their bioavailability Explore conventional dosage forms and emerging medicines Describe how pharmaceutical contribute to solving problems as “scientists” Commonly used drug testing methods

The long road to a new medicine

Examples of “Drug Discovery” at King’s Anticancer – in phase II clinical trial (Leukaemia) Iron Chelator – used in thalassemia Experimental pre-clinical drug entering into Phase I clinical trial in Pancreatic and Breast Cancer Phase II Clinical Trial in COPD

Tablet manufacturing process Tablet Press Blistering Machine

Solid oral dosage dissolution Intact tablet Disintegration Deaggregation Low rate of dissolution Moderate rate of dissolution Relatively rapid rate of dissolution Diffusion and Absorption Dissolution and diffusion Drug in molecular form Diffusion and Absorption

Routes of permeation Unstirred water layer Drug in solution Tight junction Intercellular space Basement membrane Blood capillary Transcellular Paracellular Apical cell membrane

Problems… Poor aqueous solubility of the drug Poor lipid solubility of the drug Poor chemical and biological stability (e.g. against enzymes, pH) Narrow therapeutic index Poor penetration of the Blood Brain Barrier (BBB) for treatment of brain diseases

Solutions… Addition of co-solvents, solubilisers, micronisations of drug…etc. Chemical modification to facilitate absorption across biological membranes..etc. Enteric coating of tables, encapsulation into nano-carriers…etc. Controlled release formulations Polymeric membrane Drug molecules Hydrophobic core

Examples of “Nano-carriers” at King’s DENDRIMERS Proceedings of the National Academy of Sciences USA, 2010, 107, 3966-3971 CARBON NANOTUBES VIRAL CORE PARTICLES Proceedings of the National Academy of Sciences USA, 2011, 108, 10952-7 Nature Materials, 2009, 9, 485–490 The journal of biochemistry. 2013, 153, 251-6. Drug Radionuclide siRNA LIPOSOMES Small. 2008, 4, 1406-15 Mol Pharm. 2009, 6, 520-30 Targeting ligand Hydrophilic drug Hydrophobic drug POLYMERIC NANOCAPSULES HYBRIDS

In vitro and in vivo models MONOLAYER 3D SYSTEM and CO-CULTURE 3D models (Spheroids) - Targeting + Targeting Non-endosomal Targeted NC Non targeted NC IN VIVO TESTING Blood brain barrier model Kupffer cells (liver macrophages) Cancer cells Endosomal SPECT/CT FLUORESCENCE

OPTIMISING MEDICINES DEVELOPMENT DR KHULOUD T. AL-JAMAL Institute of Pharmaceutical Science King’s College London