Depression and PER2 Andie Held studies/81244463/

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Presentation transcript:

Depression and PER2 Andie Held studies/ /

What gets you down in the dumps?

What is depression? Low mood and sadness that interferes with daily life Affects 6.7% of the adult population in the U.S. Attributable to genetic, biological, environmental, and psychological factors

PER2, Who? Light reception Regulation of circadian rhythm Always found C- terminal to PAS Ph9jPyaTtSs/UGiFJIAiECI/AAAAAAAAAlc/7FGx6NV4LSc/s1600/Day_And_Night_for_draw.jpeg; Ph9jPyaTtSs/UGiFJIAiECI/AAAAAAAAAlc/7FGx6NV4LSc/s1600/Day_And_Night_for_draw.jpeg Protein from Pfam 

Human Chimp Rhesus Monkey Dog Cattle Mouse Rat Gorilla Zebrafish 1255 How well conserved is PER2? % Identity 91% 93% 73% 77% 99% 51%

Phylogram from Clustal Omega How well conserved is PER2?

Are there natural remedies for depression?

Primary goal The primary goal of this study is to determine how the light/dark cycle affects dopamine receptor expression as well as how natural products such as valerian affect gene expression

Which model organisms should we use to study depression? 20brown%2520smile%2520old%2520young%2520teen.jpghttp://1.bp.blogspot.com/_FY8xQMCUsY8/S_MFEQzaSNI/AAAAAAAAACo/aC1euzhdlfU/s1600/group%2520diverse%2520happy%2520people%2520black%2520white%25 20brown%2520smile%2520old%2520young%2520teen.jpg; Similarity percents determined by BLAST

Aim 1: How well conserved is PER2 in blind cavefish? Alignments courtesy of Clustal Omega

Aim 2: How are PER2 and D2 dopamine receptors expressed in light/dark environments in species with different eye structures?

RNA-seq

Aim 3: How does valerian root affect PER2 protein expression?

Label free quantification; Mass spectrometry Label free quantification; Mass spectrometry

Homologs and flowchart picture references Proteins on slide 6 are curtsey of Homologene Sun Moon Fish md.pnghttp:// md.png Fish Food _500X500.jpg _500X500.jpg Valerian root isp.jpg isp.jpg Brain clip-art_ jpghttp://static.freepik.com/free-photo/cartoon-brain-outline- clip-art_ jpg

Future Directions Genetics: Further investigate the role of dopamine in depression and other natural products that regulate it Duplicate specific aim experiments with the addition of depression trigger events Social Work: Educate the public to help fight the mental illness stigma Advocate for equal access to mental health care

Resources

Questions?