At the Clinic Scenario # 1 Priscilla Angeles Physiology

Scenario # 1 A woman with excessive body hair and a deep voice shows the outward symptoms of which hormonal dysfunction? Which gland releases this hormone? Are there any other hormones involved?

Hormones Produces by the Adrenal Gland

Androgen first discovered in 1936 the original anabolic steroid precursor for all estrogens—including female sex hormones also referred to as androgenic hormone or testoid the generic term for any natural or synthetic compound—but usually only a steroid hormone stimulates or controls development and maintenance of male characteristics by binding to androgen receptors including the activity of accessory male sex organs and development of male secondary sex characteristics well known form of androgen is testosterone all hormones following slide are produced in the adrenal cortex, which is in the outer portion of the adrenal gland: dehydroepiandrosterone (DHEA) dehydroepiandrosterone sulfate (DHEA-S) androstenedione ALL FUNCTION AS A WEAK STEROID OR STEROID PRECURSOR

Dehdroepiandrosterone Androstenedione (Andro) androgenic steroid produced by the testes, adrenal cortex, and ovaries converted metabolically to testosterone and other androgens parent structure of estrone banned from being used as an athletic or body building supplement (DHEA) steroid hormone produced in adrenal cortex derived from cholesterol primary precursor of natural estrogens also called dehydroisoandrosterone or dehydroandrosterone

chemical by-product created during breakdown of androgens derived from progesterone exerts minor masculinizing effects, with one-seventh of the intensity of testosterone found in both men and women in approximately equal amounts in the plasma and urine Androsterone

Dihydrotestosterone (DHT) Metabolite of testosterone Much more potent androgen than testosterone Binds more strongly to androgen receptors Produced in the adrenal cortex Women with increased levels of DHT may develop male secondary sex characteristics, such as— Deepened voice, facial hair, and excesses hair Primary contributing factor in male pattern baldness Female hair loss is more complex, but DHT is a possible cause as well