Clozapine Therapy Training 3/10/2015. Objectives What is Clozapine used to treat? What are the major side effects of Clozapine? Why is regular blood testing.

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Presentation transcript:

Clozapine Therapy Training 3/10/2015

Objectives What is Clozapine used to treat? What are the major side effects of Clozapine? Why is regular blood testing required? Who can administer Clozapine?

Schizophrenia  Brain disorder  Chronic condition  Requires lifelong treatment

Schizoaffective Disorder  Schizophrenia Plus  Mood Disorder  Major Depression  Bipolar Disorder

Clozapine  Clozaril©  Used to treat  Schizophrenia  Schizoaffective Disorder

Clozapine HCP Orders  Must include  Specific diagnosis for which Clozapine is prescribed  Instructions to call prescribing HCP if 2 or more days of Clozapine is omitted

Clozapine HCP Orders  Any order change must be  Communicated to all staff  Documented in individual’s record as a narrative note

Documentation

Clozapine HCP Orders  Once HCP signs & dates  Valid in program for  One year [DDS]  Ninety days [DMH/DCF]

Common Side Effects  Constipation  Drooling  Sleep disorders  Increased sweating  Weight gain

Serious Side Effects  Agranulocytosis  Seizures  Orthostatic Hypotension  Bradycardia  Syncope  Myocarditis  Cardiomyopathy

Agranulocytosis  Potentially fatal blood disorder  Low White Blood Cell (WBC) count  Great risk for infection

Before starting Clozapine  HCP will order lab tests  WBC and ANC  White Blood Count and Absolute Neutrophil Count  May also be ordered as  CBC with diff  Complete Blood Count with Differential

WBC and ANC Testing  Baseline levels then,  Weekly x6 months then,  Biweekly x6 months then,  Once every 4 weeks

WBC and ANC Testing  If Clozapine is DC’d by the HCP  Weekly labs for at least 4 more weeks

Pharmacy Requirement  Current WBC & ANC levels  Current is within 7 days  Will only dispense enough Clozapine tablets until next blood test

Pharmacy Requirement  Pharmacy will not dispense Clozapine without current levels  If lab value is more than 7 days  Must be redrawn

Responsibilities  Certified staff must know  Clozapine specific system to prevent running out of meds  Upcoming lab work  Ordering/reordering

Medication Sheet

MAP Consultants  If a dose of Clozapine is missed contact the MAP Consultant  If 2 or more days are missed, do not restart without consulting the prescribing HCP first

Report Immediately  Signs and Symptoms of infection  Fever  Weakness  Lethargy  Sore throat  Confusion/Delirium

Emergency Procedures  Know  Where to locate emergency policy/procedures  When to call 911  Who to notify in the event of emergency