Sen S, Kawahara B, Chaudhuri G. Free Radic Biol Med Oct 15;53(8): doi: /j.freeradbiomed Epub 2012 Jun 27. Breast Cancer and Antioxidants: The Mechanism of Cancer Progression Sen S, Kawahara B, Chaudhuri G. Free Radic Biol Med Apr;57: doi: /j.freeradbiomed Epub 2012 Oct 23. Department of Obstetrics and Gynecology, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA 90095, USA GAUTAM CHAUDHURI

Production of Hydrogen Peroxide in Human Breast Cancer Cells: Comparison with Normal Human Breast Cells

Protein Expression /Specific Activity of Catalase in Human Breast Cancer Cells : Comparison with Normal Human Breast cells

Production of Superoxide and its Correlation to the Specific Activity of Catalase:

Silencing of Catalase Induces Growth of Human Breast Cancer Cells

Decrease in Protein phosphatase 2A ( PP2A) Activity upon Silencing of Catalase: Activity of PP2A is Dependent on the Redox State of its Thiols. MDA-MB-468

PP2A Activity was Inhibited by H 2 O 2 but Induced by α-Tocopherol (A superoxide Quencher)

Catalase SuperoxideH2O2H2O2 αTocopherol PP2AReduced Growth

Inhibition of PP2A Activity Lead to Proliferation of Human Breast Cancer cells:

Overexpression of Catalase Lead to a Reduction in H 2 O 2 Levels Accompanied by a Reduction in Cell Viability

Overexpression of Catalase Lead to Apoptosis in Human Breast Cancer cells

Overexpression of Catalase did not Induce Apoptosis in Normal Human Breast Cells

Human Breast Cancer Tissues Exhibited Higher Catalase expression but Lower Specific Activity when Compared to Normal Breast Tissues.

J Natl Cancer Inst Sep 15;85(18): J Natl Cancer Inst. Nutrition intervention trials in Linxian, China: supplementation with specific vitamin/mineral combinations, cancer incidence, and disease-specific mortality in the general population. The findings indicate that vitamin and mineral supplementation of the diet of Linxian adults, particularly with the combination of beta carotene, vitamin E, and selenium, may effect a reduction in cancer risk in this population. Ther Adv Med Oncol.Ther Adv Med Oncol Mar;6(2): Anti-inflammatory/antioxidant use in long-term maintenance cancer therapy: a new therapeutic approach to disease progression and recurrence. The high-activity catalase CC genotype was associated with an overall 17% reduction in risk of breast cancer compared with having at least one variant T allele (odds ratio = 0.83, 95% confidence interval: 0.69, 1.00). Vegetable and, particularly, fruit consumption contributed to the decreased risk associated with the catalase CC genotype. Biochem Pharmacol.Biochem Pharmacol Nov 15;82(10): doi: /j.bcp Epub 2011 Jun 13. Catalase overexpression in mammary cancer cells leads to a less aggressive phenotype and an altered response to chemotherapy. Antioxidants associated with decreased risks of Breast Cancer

Endogenous Production Of Nitric Oxide Induces Growth in Human Breast Cancer Cells (ZR & BT-474): ( Cross Talk with H 2 O 2 ) ZR-75-30

Endogenous Production Of Nitric Oxide Induces Growth in Human Breast Cancer Cells (ZR & BT-474): ( Cross Talk with H 2 O 2 )

Endogenous Production Of Nitric Oxide Does Not Induce Growth in Normal Human Breast Cells (ZR & BT-474)

Nitric Oxide Synthase Activity Present in Mitochondrial Fractions from Cancer cells

Inhibition of Nitric Oxide Formation Lowers Superoxide as well as Hydrogen Peroxide Production

Catalase Human Breast Cells Summary