We are finally starting to unravel the missing link between nature and nuture; how our environment talks to us, sometimes forever. Nessa Carey, The Epigenetics.

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Presentation transcript:

We are finally starting to unravel the missing link between nature and nuture; how our environment talks to us, sometimes forever. Nessa Carey, The Epigenetics Revolution (2012)

The epigenetics revolution is underway. Nessa Carey, The Epigenetics Revolution (2012)

Sharon Moalem, Inheritance (2014) What we are now learning is that our genes are part of a larger flexible network. This is contrary to what we’ve been told about our genetic selves. Our genes aren’t fixed and rigid as most of us have been led to believe.

Today no one doubts that epigenetic effects play a crucial role in development, aging and even cancer. Michael Skinner, A New Kind of Inheritance (2014)

In the 21 st century it is the new scientific discipline of epigenetics that is unraveling so much of what we took as dogma and rebuilding it in an infinitely more varied, more complex, and even more beautiful fashion. Nessa Carey, The Epigenetics Revolution (2012)

….for some very specific situations Lamarckian inheritance is taking place. Nessa Carey, The Epigenetics Revolution (2012)

Understanding epigenetics and epigenomics will be essential in work related to many other topics requiring a thorough understanding of all aspects of genetics, such as stem cells, cloning, aging, synthetic biology, species conservation, evolution, and agriculture. Bob Weinhold, Epigenetics: The Science of Change (2006)

Sharon Moalem, Inheritance (2014) The thing Mendel couldn’t see in his peas- and that generations of geneticists continued to miss after his death- is that it’s not only what our genes give to us that’s important but also what we give to our genes […] nurture can and does trump nature.

Now it appears that our diets and lifestyles can change the expression of our genes. How? By influencing a network of chemical switches within our cells collectively known as the epigenome. NOVA’s Ghost in Your Genes (2006)

Epigenetic effects occur not just in the womb, but over the full course of a human life span. Bob Weinhold, Epigenetics: The Science of Change (2006)

The most important effect of epigenetic marks – maybe their reason for existing – might be to wildly expand the number of variant individuals in a population. Michael Skinner, A New Kind of Inheritance (2014)

The evidence linking epigenetic processes with cancer is becoming extremely compelling...[they] account for one-third to one-half of known genetic alterations [in cancer]. Bob Weinhold, Epigenetics: The Science of Change (2006)

“I am biased, but the tip of the iceberg is genomics and single-nucleotide polymorphisms. The bottom of the iceberg is epigenetics.” Randy Jirtle to Bob Weinhold (2006)

“And there’s much more potential for the epigenome to be affected [in cancer, atherosclerosis, Alzheimer’s disease] than the genome itself. It’s just more fluid and more easy to be the culprit.” Jean-Pierre Issa to Ken Garber (2006)

But nurture matters too. Many of the contingencies of life- what we eat, what pollutants are in our environment, how often we are stressed – affect how the genes operate. Michael Skinner, A New Kind of Inheritance (2014)