Management of Sporadic Desmoid-type Fibromatosis: A European Consensus Approach based on Patients’ and Professionals’ Expertise - EORTC/STBSG and SPAEN.

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Presentation transcript:

Management of Sporadic Desmoid-type Fibromatosis: A European Consensus Approach based on Patients’ and Professionals’ Expertise - EORTC/STBSG and SPAEN Initiative 18 th of October 2014, CTOS 2014, InterContinental Berlin Hotel, Berlin, Germany Bernd Kasper Mannheim University Medical Center on behalf of the Desmoid Working Group

Background  Desmoid-type fibromatosis (DF) describes a rare monoclonal, fibroblastic proliferation characterized by a variable and often unpredictable clinical course.  The incidence is < 3 % of all STS with a peak age of around 30 years.  Surgery remains a valid option, however, function preservation and quality of life are essential.  Systemic treatment approaches comprise: - Antihormonal therapy (+ NSAID) - Chemotherapy - Tyrosine kinase inhibitors  A Watch & Wait strategy is currently agreed to be most appropriate as front-line approach. Kasper B et al. Oncologist 2011; 16:

Treatment Strategies  There is no evidence-based treatment approach available as of today.  In contrast, there are lots of open questions: - Which patients should be treated? - Which treatment should be selected? - When is the right time to start treatment? - …  A case by case discussion in a MDT including the patient’s wish is essential to propose a personalized management approach.  Consider that DF is a benign disease and that the patient’s quality of life should be the focus in treatment decision making.  Need for a consented approach! Kasper B et al. Oncologist 2011; 16:

Watch & Wait Strategy Fiore M et al. Ann Surg Oncol 2009; 16:

Watch & Wait Strategy resectable ? Desmoid Tumor Observation Resection Systemic Therapy Oberservation margins ? Radiation Therapy Oberservation ? Alternative Therapy ? Yes No Negative Positive adequate response inadequate response Reassessment in the case of progression/recurrence Kasper B et al. Oncologist 2011; 16:

Watch & Wait Strategy Gronchi A et al. Ann Oncol 2014; 25:

1 st SPAEN Desmoid Round Table Meeting on 8 th of May 2014 Task Force Members:Medical Experts: Christina Baumgarten, SPAEN, Germany (Chair)Prof. Bernd Kasper, Mannheim, Germany (Coordinator) Barbara Dore, SPAENDr. Palma Dileo, London, UK Sarka Duskova, CzechoslovakiaProf. H.R. Dürr, Munich, Germany Claire Kelleher, Sarcoma UKProf. Winette van der Graaf, Nijmegen, The Netherlands Georges Moreau, sos desmoid, FranceProf. Alessandro Gronchi, Milano, Italy Markus Wartenberg, Das Lebenshaus, GermanyDr. Rick Haas, Amsterdam, The Netherlands Hilly van der Zande, The NetherlandsDr. Sam Hacket, London, UK Prof. Florian Haller, Erlangen, Germany Prof. Peter Hohenberger, Mannheim, Germany Prof. Christoph Kettelhack, Basel, Switzerland Dr. K. Kubackova, Prague, Czech Republic PD Dr. Lars Lindner, Munich, Germany Dr. Odile Oberlin, Villejuif, France Dr. Daniel Vanel, Bologna, Italy

Joint Effort STBSG and SPAEN What can Health Professionals provide?  May provide retrospective data / analysis on DF patients.  Can share their expertise in treating DF patients.  May provide evidence on DF treatment through conducting clinical studies.  Provide expertise to focus on the most promising research projects.  Can jointly develop a consented treatment algorithm and paper.

Joint Effort STBSG and SPAEN What can Patient Advocacy Groups provide?  Are a helpful voice in understanding patients’ problems and needs.  Can reinforce explanations given by experts to avoid misunderstanding.  May provide common issues of DF patients which experts hardly see.  Help to identify highly experienced experts / centers or networks of excellence.  Play a fundamental role to connect people, information and resources.

Joint Effort STBSG and SPAEN What can Patient Advocacy Groups provide?  Support spreading information which is not widely known.  Can help patients to receive diagnosis and treatment in a timely manner.  Draw experts’ attention to the fact that pain burden is underestimated in DF patients.  Remind experts that psychological support is needed for many of the young patients.  Can jointly develop a consented treatment algorithm and paper.

Draft (Core Team) 1-4/2014 Meeting 5/2014 Paper 6-9/2014 Approval 10/2014 Publication 11-12/2014 Workflow

Topics covered in the consensus paper:  Pathology / Molecular Biology  Imaging  Surgery  Radiotherapy  Medical Therapy  Pain Control and Quality of Life  DF and Pregnancy  Consensus Algorithm

Pathology / Molecular Biology:  A biopsy confirming DF diagnosis is mandatory.  DF diagnosis has to be confirmed by an expert pathologist.  Immunostaining for ß-catenin with nuclear positivity in DF is helpful in establishing the diagnosis.  Mutational analysis of ß-catenin is currently not part of the routine diagnostic work-up, however, it may be a specific diagnostic tool for establishing DF diagnosis.

Imaging:  Magnetic resonance imaging (MRI) is the main imaging modality.  The low signal intensity, infiltrative pattern and multiplicity are suggestive of DF diagnosis.  Anyway, a histological proof is always needed.  FDG/PET may be used as a surrogate marker helping to predict response to therapy early in the course of treatment.

Surgery:  Before 2000, surgery with negative margins had been considered the standard of care for patients affected by DF.  A reassessment of the overall management has taken place over the last few years, and preservation of function became a priority.  To further limit morbidity and to minimize overtreatment an initial observation period is proposed for (roughly) all patients.  When the observational approach fails, surgery is still a valid option and should aim to obtain microscopic negative margins.

Radiotherapy:  In case of R0 resections, there is no indication for postoperative radiotherapy.  Adjuvant radiotherapy reduces the risk of recurrence and may be an option especially for patients operated for recurring disease.  Note that the average DF patient is young with a life expectancy of decades and can therefore be subject to late radiation toxicity.  Radiotherapy as single modality has been shown to provide adequate local control in the majority of progressive patients (EORTC data).

Medical Therapy:  Antihormonal agents, alone or in combination with NSAIDs, may be given, however, a general recommendation for its use could not be given.  For aggressively growing and / or symptomatic or even life-threatening DF chemotherapy is advisable.  Due to its activity with acceptable and less cardiac toxicity, pegylated liposomal doxorubicin is considered treatment of choice by many investigators, preferably in this young patient population.  There is prospective evidence for the activity of imatinib with high rates of stabilization despite low response rates of max %.  We are not in the situation to propose a definitive order of the existing systemic treatment options (stepwise approach seems reasonable).

Pain control and quality of life:  DF is often associated with symptoms of pain and discomfort.  Pain should be treated independently from the DF itself according to existing standards.  It should always be considered that DF is a benign disease and that the quality of life of the patient should be the focus in treatment decision making.  It is recommended to offer patients psychological and social support; DF management requires collaboration with algologists + physiotherapists.

DF and Pregnancy:  Many women who present with DF have had a recent pregnancy.  According to a recent retrospective publication pregnancy-related DF has good outcomes.  The progression risk during pregnancy is high, but it can be safely managed.  DF should not be a contradiction to future pregnancy.

Diagnosis (core needle biopsy) Front-line approach: Watch & Wait (1–2 years) In case of Progression (consider - if clinically possible - to wait until 3 subsequent progression) In case of Progression (consider - if clinically possible - to wait until 3 subsequent progression) Investigational agents, … Abdominal wall Head & neck / intrathoracic Head & neck / intrathoracic MT RT or S* + RT Abbreviations:HT: Hormonal therapy; S: Surgery; S*: Surgery is an option if morbidity is limited; MT: Medical therapy; RT: Radiotherapy; CT: Chemotherapy; ILP: Isolated limb perfusion; HY: Hyperthermia In case of Stabilization or Regression: Watch & Wait Intra- abdominal Retroperito- neal / pelvic CT (no RT) CT (no RT) MT S*/RT or both S* MT Extremity / girdles / chest wall S* ILP MT RT CT+HY S S HT

Joint publication effort between EORTC/STBSG & SPAEN Management of sporadic desmoid-type fibromatosis: A European consensus approach based on patients’ and professionals’ expertise - A European Organisation for Research and Treatment of Cancer (EORTC) / Soft Tissue and Bone Sarcoma Group (STBSG) and Sarcoma Patients EuroNet (SPAEN) initiative B. Kasper, C. Baumgarten, S. Bonvalot, R. Haas, P. Hohenberger, G. Moreau, W.T.A. van der Graaf, A. Gronchi on behalf of the Desmoid Working Group

Take-Home-Messages I  No evidence-based DF treatment approach available as of today.  Proposal for a European consensus treatment algorithm for sporadic desmoid-type fibromatosis.  Consensus approach based on professionals’ (EORTC/STBSG) AND patients’ (SPAEN) expertise - for the first time ever in this disease!  Strong collaboration / partnership between professionals and patient advocates is important to close the lack of information and to help patients to understand this complex rare disease.

Take-Home-Messages II  A Watch & Wait strategy is currently agreed to be most appropriate as front-line approach as a fundamental basis of the treatment algorithm.  Surgery remains a valid option, however, function preservation and quality of life are essential.  Medical treatment is indicated when local therapy is infeasible or associated with severe function loss or morbidity; however, it is not possible to propose a definitive order of the existing systemic treatment options.  There is an unmet medical need for more evidence-based data in this rare disease.

Thanks for all input and the joint effort!