Bioassay with cultured ganglia. Transport of NGF.

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Presentation transcript:

Bioassay with cultured ganglia

Transport of NGF

Structure of neurotrophins

Structure of neurotrophin receptors

Neurotrophin receptor specificity

Tyrosine kinase Receptor activation:

Tyrosine kinase Receptor activation:

Distribution of brain neurotrophins

Signaling Pathways:

MAP kinase cascade:

“Caretaker” neurotrophins during outgrowth

Growth factors in the CNS

Depolarization and Ca influx enhances growth factor expression

Sensory input and growth factor activity throughout development

Diffusible factor from mouse sarcoma

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