Research Presentation Nordborg Lab University of Southern California Helly Kwee August 21, 2003 Southern California Bioinformatics Summer Institute.

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Presentation transcript:

Research Presentation Nordborg Lab University of Southern California Helly Kwee August 21, 2003 Southern California Bioinformatics Summer Institute

Agenda Research area overview Projects Bioinformatics Tools Current State of Affairs Conclusion (Impacts)

Overview Genetic basis of adaptation Map loci conferring natural variation in Arabidopsis thaliana NSF 2010 Project

Projects Genomic survey of polymorphism in A. thaliana – Sequence ~2000 fragments from 96 accessions – Phenotype various traits – Association analysis Bioinformatics tools: – Publicly accessible database – Web-based viewers

Bioinformatics Tools Revised database schema Populating the database Revised web-based viewers – Genome – Polymorphism – Alignment

Database Contents

Code Revision I alignmentviewer.pl db.pm viewer.pm alignmentviewer.pl genomeviewer.pl polymorphismviewer.pl genomeviewer.pl polymorphismviewer. pl Module s

Screenshot-- Alignment Viewer

Screenshot– Genome Viewer Screenshot-- Genome Viewer

Screenshot-- Polymorphism Viewer

Impacts Insights into genetic basis of natural variation Genes responsible for agriculturally important traits Tools and methods --> applicable to economically important organisms Database as training tool

Questions ?

Acknowledgements Dr. Nordborg and his lab SoCalBSI faculty NSF and NIH