John Heuser Synaptotagmin SNARE Complex VGCC Ca 2+

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Presentation transcript:

John Heuser

Synaptotagmin SNARE Complex VGCC Ca 2+

Synaptotagmin SNARE Complex VGCC

Ca 2+ Synaptotagmin SNARE Complex VGCC

Diffusion

Fick’s First Law of Diffusion

distance concentration flux -

Fick’s Second Law of Diffusion

distance concentration - + flux

Fick’s Second Law of Diffusion distance concentration - + flux -

Calcium Buffers

Membrane Calcium Pumps

VGCC local calcium global calcium

VGCC local calcium global calcium

BAPTA EGTA

Squid giant synapse

EGTABAPTA

Fluorescent Calcium Dyes

10 μm

photolysi s Uncaged Calcium Caged Calcium Calcium Cage

The Calyx of Held

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