IR-4 National Meeting Sept 2007 Nichino America Inc. Jim Adams, Manager, Product Development Marie Maks-Regulatory Affairs Manager Web site:

ET® Herbicide/Defoliant (Pyraflufen-Ethyl)

Commercial Brands ET® 2.5 % EC Edict ® 2% SC Venue ® 2SC Octane Venue

Structure/Activity Chemical Name: ethyl 2-chloro-5-[4-chloro-(5- difluoromethoxy)-1-methyl-1H-pyrazol-3-yl]-4- fluorophenoxyacetate CAS Number: Formula: C 15 H 13 Cl 2 F 3 N 2 O 4 Molecular Weight: Common Name: Pyraflufen-ethyl Code Number: ET-751 Trade Name: ET Mode of Action: Protox inhibitor 30 day plantback based on confined crop rotation study; very quick degradation in environment seen in field soil dissipation studies

Generally used in mixtures  Defoliants  Glyphosate  2,4-D  SU’s  Others Fallow/Eco-fallow Pre-plant / Post-harvest weed control Post directed weed control (cotton) Cotton Defoliation Use Pattern

ET Broadens Adoption of IPM Chemistry: Structure different from other protox inhibitors Excellent activity on morningglory, Amaranthus spp., wild buckwheat, Russian thistle, prickly lettuce and field bindweed, as well as other broadleaf weeds Controls ALS-resistant kochia, hemp sesbania, and tall water hemp Used in place of tribufos and in combination with defoliants and desiccants in cotton.

2008/9 Expected Section 3 In-crop use in wheat, corn, soybeans (ET® 2.5 EC)  Tolerances mid-2008, commercial launch 2009 Pasture / rangeland mid-2008 (Edict® SC)  Probable launch 2008  Excellent activity mixed with 2,4-D against leafy spurge for grass release programs in the western USA

Future label additions Preplant to all major annual crops (ET) Post-bloom use in TNV (Venue)

IR-4 Interests Hops (WA) Sesame oil Priority C (TX) Watercress Priority C (FL) Leafy greens ( ) Priority ?

Nichino America Inc. Website: