Preventative and Therapeutic treatment of resveratrol on Alzheimer’s Disease using CL2006 and CL4176 C. elegan models Bradford Greaves.

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Presentation transcript:

Preventative and Therapeutic treatment of resveratrol on Alzheimer’s Disease using CL2006 and CL4176 C. elegan models Bradford Greaves

Need

Amyloid Beta Production

Alzheimer’s Disease cont.

Oxidative Damage

The APP Processing Senile Plaques Modified from Laurén et al., Nature (2009) Figure 1 Resveratrol Promotes Clearance of Alzheimer’s Disease Amyloid- Peptides, Marambaud 2005 The β amyloid peptide can act as a modular aggregation domain, Link 2008

Figure 2 Soy isoflavone glycitein protects against beta amyloid-induced toxicity and oxidative stress in transgenic Caenorhabditis elegans, Gutierrez-Zepeda 2005 Transgenic C. elegans as a Model in Alzheimer’s Research, Wu 2005

Purpose To preventatively and therapeutically treat Alzheimer’s Disease with resveratrol using CL2006 and CL4176 C. elegan models

Hypothesis Alternate Hypothesis: Both preventive and therapeutic treatment of resveratrol on CL2006 will lead to a decrease in amyloid beta production and for CL4176 there will be a delay of the onset of paralysis. Null Hypothesis: There will be no change in amyloid beta production nor paralysis with the addition of resveratrol.

Resveratrol’s Coloration With Alzheimer’s Disease

Do Ability CL2006 and CL4176: Staining and Paralysis Control food and Resveratrol available Fluorescent Microscope at school Prism not known (GFP)

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