The Value of Real Time Pharmacokinetic and Pharmacodynamic Modeling in Critical Care.

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Presentation transcript:

The Value of Real Time Pharmacokinetic and Pharmacodynamic Modeling in Critical Care

Pharmacodynamic Modeling (V 1 ) Central Compartment (V 2 ) Rapid Peripheral Compartment (V 3 ) Slow Peripheral Compartment (V e ) Effect Site Infusion Pumps Bar-coded Bolus Syringes Pharmacokinetic Models Drug delivery devices

Syroid N, Anesth 2002;96:

[remi] (ng/ml) [prop] (ug/ml) (a) [remi] (ng/ml) [prop] (ug/ml) (b) (c) [prop] (ug/ml) [remi] (ng/ml) [prop] (ug/ml) [remi] (ng/ml) (d)

Return of Responsiveness

Laryngoscopy Mertens and Kern

Effect Path

Figure 2 – Analgesia Level (Control) Analgesia Level (Display) Skin Incisions Artho-scopic Procedure Bankart Procedure Maintenance Phase Time (min) Level of Pain/Analgesia

Experiment 1: Results Heart Rate *

Experiment 1: Results Blood Pressure *

* * * *

Anesthesia Advisory Display: Real time guidance through the pharmacokinetic and interaction pharmacodynamic relationship during simultaneous administration of multiple drugs. Schumacher, Bouillon, Leibundgut, Sartori, Zbinden, ASA 2004

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