Your first mentored grant proposal: The National Institutes of Health F and K proposals, and Foundations Alison K. Hall, Ph.D. Case School of Medicine Office of Graduate Education

You are at a critical juncture in training productive self-reliant about to embark on independent careers becoming physician-scientists Often write a grant to seek financial support and recognition for research

Why do you want a mentored grant? 1.Makes the relationship with the PI explicit 2.Benefits associated with grant 3.Looks good on your resume 4.Great learning experience 5.The future inclues an R01…

The Number of Pre-Doctoral and Post-Doctoral Research Training Positions on NIH Training Grants and Fellowships (NRSA) Fiscal Year 2005

Where do you start? Communicate your PI, potential mentors your chairperson the Office of Research/ Univ Review, compliance Are you ready? pilot data time to focus deadlines Do you qualify? appointment status US citizens, permanent residents

The Number of Research Training Positions on NIH Training Grants and Fellowships (NRSA) Fiscal Years

Number of Fellowship (F31) Applications Reviewed and Awarded Fiscal Years 1990 – 2005

The F30 National Research Service Award (NRSA) for individual Predoctoral MD/PhD fellows set stipend scale and supplement

The F32 NRSA Jan. 9, 2006 Stipends for Kirschstein-NRSA awards 2006 Postdoctoral Years of Experience: 0$36,996 1$38,976 2$41,796 3$43,428 4$45,048 5$46,992 6$48,852 7 or more $51,036 Institutional Allowance $5,500 Research supplies, health insurance, travel to mtgs Program announcements

Components of Participating Organizations National Institute on Aging (NIA/NIH), ( ) National Institute on Alcohol Abuse and Alcoholism (NIAAA/NIH), ( ) National Institute on Deafness and Other Communication Disorders (NIDCD/NIH), ( ) National Institute on Drug Abuse (NIDA/NIH), ( ) National Institute of Environmental Health Sciences (NIEHS/NIH), ( ) National Institute of Mental Health (NIMH/NIH), ( ) National Institute of Neurological Disorders and Stroke (NINDS/NIH), ( ) Office of Dietary Supplements (ODS/NIH), ( ) April 5 August 5 December 5 Individual fellowships (F31) for minority students or students with disabilities have special receipt dates

The F31 NRSA There are some 25 Institutes at NIH that each have mission Look at CRISP database As director of the National Institute of General Medical Sciences from 1974 to 1993, Ruth Kirschstein MD was the first woman institute director at the National Institutes of Health (NIH). Throughout her career, she has worked as an administrator, fundraiser, and scientific researcher, investigating possible public health responses in the midst of crisis and conservatism.

Stipends20,772 (suppplement) Tuition and fees (formula) Health insurance Institutional Allowance 30 fellows receive an institutional allowance of $2,750 per 12- month period to non-federal, or nonprofit sponsoring institutions to help defray such awardee expenses as research supplies, equipment, books, and travel to scientific meetings.

2002 Number number total cost success reviewed awarded awarded 1000s rate* MD202914,60245 PHD1, , all1, , The F32 NRSA is a reasonable goal:

Grant NumberPI NameProject Title 5F32GM ARMBRUSTER, BLAINECreation of designer biogenic amine receptorsCreation of designer biogenic amine receptors 5F30DC BALU, RAMANIIntrinsic properties of olfactory bulb mitral cellsIntrinsic properties of olfactory bulb mitral cells 5F30NS COWAN, THOMASAssistive Device Control With Brain Surface SignalsAssistive Device Control With Brain Surface Signals 1F31NR A 2DIMARCO, MARGUERITEUtilization Dental Care by Homeless ChildrenUtilization Dental Care by Homeless Children 5F30ES ETLING, MICHELEInitiation of Experimental Colitis by Commensal FloraInitiation of Experimental Colitis by Commensal Flora 5F31HD JAGODNIK, KATHLEENUpper Extrem. Control Using Reinforcement LearningUpper Extrem. Control Using Reinforcement Learning 5F31MH LERCH, JESSICAMolecular Genetics of the Serotonin SystemMolecular Genetics of the Serotonin System 5F31NR MURROCK, CAROLYNDance and Physical Activity in Afr. American WomenDance and Physical Activity in Afr. American Women 1F32AA PRITCHARD, MICHELEEgr-1 and EtOH-induced hepatic leukocyte recruitmentEgr-1 and EtOH-induced hepatic leukocyte recruitment 5F31HD ROHDE, TREENAPREDOC FELLOWSH FOR STUDENTS WITH DISABILITIESPREDOC FELLOWSH FOR STUDENTS WITH DISABILITIES 5F31MH SAMUELS, IVYERK2 Specific Function of the CNSERK2 Specific Function of the CNS 1F32CA A1 SWEENEY, COLINRetroviral Insertional Mutagenesis in LMO1 Stem CellsRetroviral Insertional Mutagenesis in LMO1 Stem Cells 5F32AG WILKINSON, BRANDYMechanisms of Abeta-Stimulated ROS in Microglia

Prepare the Application: read the instructions!! start early, seek internal reviewers a.Candidate US citizen or permanent resident Doctoral degree (many ok) b.Sponsor and Training Environment c.Research Proposal Up to 3 yrs c.Training Potential-impt! d.Vertebrate Animals, Human Subjects etc. e.Three letters of reference f.3 times per year, usu Apr 5, Aug 5, Dec 5 The A1 or A2. You may have to resubmit…

NRSA Review Criteria Candidate: previous academic and research performance potential to become an important contributor Sponsor and Training Environment: quality of the training environment qualifications of the sponsor as a mentor for the proposed research training experience. Research Proposal: merit of the scientific proposal relationship to the candidate's career plans. Training Potential: value of the proposed fellowship experience as it relates to the candidate's needs in preparation for a career as an independent researcher.

The K08 Mentored Clinical Scientist Development Award For clinically trained persons to pursue research careers in basic or clinical sciences. Must apply within 3 years of clinical Training (residency +1 year of clinical fellowship) K08->K02-> R01 up to $85,000 salary up to $50,000 costs/ year up to five years, non-renewable

The K08 Prepare the Application: read the instructions!! a.Candidate b.Research Plan c.Career Development Plan/ Training Plan d.Environment/ Institutional support e.Mentor* f.Vertebrate Animals, Human Subjects etc. g.The A1 or A2. You may have to resubmit… h.(The summary statement)

The K08 Candidate** **some Institutes require faculty app’t (eg Instructor) Basic Science Mentor/co Mentor: 1.Good working relationship 2.Often funded by NIH 3.Expert in this area 4.Experienced trainer

The K08 Career Development Plan (very important) Focused and relevant New techniques, new area, could be funded Present at meetings, review grants, external courses Update didactics Create an oversight committee familiar with research, career goals, meet six mos for feedback

Research Plan Provide preliminary data to support rationale, approach. Focus! Include study of Research Ethics, animals etc.

The K08 See supplementary info at each institute Insure protected time -Do not assume that 75% means anything except 75% of your total working hours -These estimates are carefully reviewed essential that your chair state this not contingent on receipt of the grant -50% Neurosurgery

What happens to your application after it leaves the mailbox? Center for Scientific Review receives the application assigned to the Initial review group or “Study section” Review for SCIENTIFIC MERIT and TRAINING POTENTIAL. Summary statement, see NIH Commons Scores and percentiles. NRSAs are not streamlined Priority score , with 100 is best. Rewrite? Respond to critique Funded?Progress report each year

Inside the NIH Grant Review Process 39 min video NIH Center for Scientific Review Includes R01/K08/ R03 Download proposals View the video on the web Helpful Hints for an NLHBI K08 Application

Grantwriting Resources Grantpersonship: An Instruction Manual NIMH Grant Application Process FASEB Grantsmanship Training Program Grant Application Writer’s Handbook, Reif-Lehrer

What about foundations and organization fellowships? Public charitable organizations- MDA, AHA, ACS Derives support from members of the public Foundations-Private, Corporate derives support from a family, individual or corporation see The Foundation Center (Richard Sohn, Research Admin has subscr.) often have a disease focus may support non US citizens Often have one deadline per year

Where to find these other grants? Grantsnet “Initial MD postdoc, dermatology, skin” examples: 18. LRF Postdoctoral Fellowship Awards Program Sponsor: Medical Foundation Program Type: Anatomy, Biochemistry, Bioengineering, Bioinformatics, Biology, Biophysics, Cell Biology, Chemistry, Developmental Biology, Immunology, Microbiology, Molecular Biology, Physiology, Structural Biology Deadline(s): 11/15/ Research Grants Sponsor: American Skin Association, Inc. Program Type: Biology, Cancer, Cell Biology, Clinical Research, Developmental Biology, Disease-Specific Research Skin Cancer/Melanoma, Psoriasis, Epidemiology, Immunology, Molecular Biology, Structural Biology, Other (specify): Vitiligo, Childhood Skin Diseases/Disfigurement, Pigment Cell Biology and Auto-immune Inflammatory Skin Diseases Deadline(s): 10/03/2005