Class 5 Hidden Markov models. Markov chains Read Durbin, chapters 1 and 3 Time is divided into discrete intervals, t i At time t, system is in one of.

Slides:



Advertisements
Similar presentations
. Inference and Parameter Estimation in HMM Lecture 11 Computational Genomics © Shlomo Moran, Ydo Wexler, Dan Geiger (Technion) modified by Benny Chor.
Advertisements

Marjolijn Elsinga & Elze de Groot1 Markov Chains and Hidden Markov Models Marjolijn Elsinga & Elze de Groot.
HMM II: Parameter Estimation. Reminder: Hidden Markov Model Markov Chain transition probabilities: p(S i+1 = t|S i = s) = a st Emission probabilities:
Hidden Markov Model.
Hidden Markov Models Chapter 11. CG “islands” The dinucleotide “CG” is rare –C in a “CG” often gets “methylated” and the resulting C then mutates to T.
Rolling Dice Data Analysis - Hidden Markov Model Danielle Tan Haolin Zhu.
. Markov Chains as a Learning Tool. 2 Weather: raining today40% rain tomorrow 60% no rain tomorrow not raining today20% rain tomorrow 80% no rain tomorrow.
Bioinformatics Hidden Markov Models. Markov Random Processes n A random sequence has the Markov property if its distribution is determined solely by its.
Hidden Markov Models Eine Einführung.
 CpG is a pair of nucleotides C and G, appearing successively, in this order, along one DNA strand.  CpG islands are particular short subsequences in.
Patterns, Profiles, and Multiple Alignment.
Hidden Markov Models Modified from:
Hidden Markov Models Ellen Walker Bioinformatics Hiram College, 2008.
Statistical NLP: Lecture 11
Hidden Markov Models Fundamentals and applications to bioinformatics.
Natural Language Processing Spring 2007 V. “Juggy” Jagannathan.
Hidden Markov Models 1 2 K … 1 2 K … 1 2 K … … … … 1 2 K … x1x1 x2x2 x3x3 xKxK 2 1 K 2.
GS 540 week 6. HMM basics Given a sequence, and state parameters: – Each possible path through the states has a certain probability of emitting the sequence.
Hidden Markov Model 11/28/07. Bayes Rule The posterior distribution Select k with the largest posterior distribution. Minimizes the average misclassification.
. Parameter Estimation and Relative Entropy Lecture #8 Background Readings: Chapters 3.3, 11.2 in the text book, Biological Sequence Analysis, Durbin et.
Hidden Markov Models I Biology 162 Computational Genetics Todd Vision 14 Sep 2004.
CpG islands in DNA sequences
Temporal Processes Eran Segal Weizmann Institute.
Hidden Markov Models K 1 … 2. Outline Hidden Markov Models – Formalism The Three Basic Problems of HMMs Solutions Applications of HMMs for Automatic Speech.
Lecture 9 Hidden Markov Models BioE 480 Sept 21, 2004.
Hidden Markov Models Usman Roshan BNFO 601. Hidden Markov Models Alphabet of symbols: Set of states that emit symbols from the alphabet: Set of probabilities.
Bioinformatics Hidden Markov Models. Markov Random Processes n A random sequence has the Markov property if its distribution is determined solely by its.
1 Hidden Markov Model Instructor : Saeed Shiry  CHAPTER 13 ETHEM ALPAYDIN © The MIT Press, 2004.
Hidden Markov Models Usman Roshan BNFO 601. Hidden Markov Models Alphabet of symbols: Set of states that emit symbols from the alphabet: Set of probabilities.
Hidden Markov Models.
Probabilistic Model of Sequences Bob Durrant School of Computer Science University of Birmingham (Slides: Dr Ata Kabán)
Hidden Markov Models. Hidden Markov Model In some Markov processes, we may not be able to observe the states directly.
Hidden Markov models Sushmita Roy BMI/CS 576 Oct 16 th, 2014.
Learning HMM parameters Sushmita Roy BMI/CS 576 Oct 21 st, 2014.
Visual Recognition Tutorial1 Markov models Hidden Markov models Forward/Backward algorithm Viterbi algorithm Baum-Welch estimation algorithm Hidden.
Dishonest Casino Let’s take a look at a casino that uses a fair die most of the time, but occasionally changes it to a loaded die. This model is hidden.
1 Markov Chains. 2 Hidden Markov Models 3 Review Markov Chain can solve the CpG island finding problem Positive model, negative model Length? Solution:
Machine Learning CUNY Graduate Center Lecture 21: Graphical Models.
HMM Hidden Markov Model Hidden Markov Model. CpG islands CpG islands In human genome, CG dinucleotides are relatively rare In human genome, CG dinucleotides.
. Parameter Estimation For HMM Lecture #7 Background Readings: Chapter 3.3 in the text book, Biological Sequence Analysis, Durbin et al., 2001.
BINF6201/8201 Hidden Markov Models for Sequence Analysis
Fundamentals of Hidden Markov Model Mehmet Yunus Dönmez.
H IDDEN M ARKOV M ODELS. O VERVIEW Markov models Hidden Markov models(HMM) Issues Regarding HMM Algorithmic approach to Issues of HMM.
Hidden Markov Models Yves Moreau Katholieke Universiteit Leuven.
Hidden Markov Models Usman Roshan CS 675 Machine Learning.
Hidden Markov Models BMI/CS 776 Mark Craven March 2002.
CS5263 Bioinformatics Lecture 10: Markov Chain and Hidden Markov Models.
S. Salzberg CMSC 828N 1 Three classic HMM problems 2.Decoding: given a model and an output sequence, what is the most likely state sequence through the.
Hidden Markov Models & POS Tagging Corpora and Statistical Methods Lecture 9.
PGM 2003/04 Tirgul 2 Hidden Markov Models. Introduction Hidden Markov Models (HMM) are one of the most common form of probabilistic graphical models,
Hidden Markov Models 1 2 K … 1 2 K … 1 2 K … … … … 1 2 K … x1x1 x2x2 x3x3 xKxK 2 1 K 2.
CSC321: Neural Networks Lecture 16: Hidden Markov Models
Hidden Markovian Model. Some Definitions Finite automation is defined by a set of states, and a set of transitions between states that are taken based.
Algorithms in Computational Biology11Department of Mathematics & Computer Science Algorithms in Computational Biology Markov Chains and Hidden Markov Model.
Hidden Markov Models (HMMs) Chapter 3 (Duda et al.) – Section 3.10 (Warning: this section has lots of typos) CS479/679 Pattern Recognition Spring 2013.
1 DNA Analysis Part II Amir Golnabi ENGS 112 Spring 2008.
ECE 8443 – Pattern Recognition ECE 8527 – Introduction to Machine Learning and Pattern Recognition Objectives: Reestimation Equations Continuous Distributions.
Hidden Markov Model Parameter Estimation BMI/CS 576 Colin Dewey Fall 2015.
Hidden Markov Models. A Hidden Markov Model consists of 1.A sequence of states {X t |t  T } = {X 1, X 2,..., X T }, and 2.A sequence of observations.
Data-Intensive Computing with MapReduce Jimmy Lin University of Maryland Thursday, March 14, 2013 Session 8: Sequence Labeling This work is licensed under.
Other Models for Time Series. The Hidden Markov Model (HMM)
Bayan Turki Bagasi.  Introduction  Generating a Test Sequence  Estimating the State Sequence  Estimating Transition and Emission Matrices  Estimating.
Lecture 16, CS5671 Hidden Markov Models (“Carnivals with High Walls”) States (“Stalls”) Emission probabilities (“Odds”) Transitions (“Routes”) Sequences.
Hidden Markov Models BMI/CS 576
V5 Stochastic Processes
1.
Three classic HMM problems
Hidden Markov Models (HMMs)
CSE 5290: Algorithms for Bioinformatics Fall 2009
CSCI 5582 Artificial Intelligence
Presentation transcript:

Class 5 Hidden Markov models

Markov chains Read Durbin, chapters 1 and 3 Time is divided into discrete intervals, t i At time t, system is in one of a finite set of states, x i For each pair of states, s and t, there is a probability of transition from s to t, a st

Example: The drunkard’s walk A drunk (D) in Lineland ‘paces’ in a room of length 4 (positions -2, -1, 0, 1, 2) In each time step, he takes one step forward or backward at random From the ‘wall’ (-1, 1), he can only take a step away

Transition matrix representation 2D table, with all possible states on x and y axes each cell, a st, is probability of transition from x s to x t write a transition matrix for the Lineland drunk D do you see constraints on the row, column sums?

Finite state machine representation Each state is a node in a graph Each (directed) edge is a transition The edge weight is the probability of the transition Draw the fsm for the Lineland drunk D

Begin and end states It is possible to add a begin state B to drunkard’s walk This corresponds to an entrance It is possible to add an end state E to drunkard’s walk This corresponds to an exit (trapdoor) E is usually omitted (=> walk of arbitrary length)

Where to find D? Assume D enters at position 0 Calculate the probability of his position at times Do the probabilities stabilize? What is the meaning of the pattern which emerges?

What if room is odd length? Calculate for t = 0..5 (now) for room of size (-1,.. 2) HW problem: Find P i as t become large

Another variation If D is not at a wall, he may move left, right or not all all, with equal probability If D is at a wall, he may move away or not all all, with equal probability For room (-1, 0, 1), give the transition matrix Calculate D’s probable state at times 0.. 5

Keeping more history We’ve assumes that transition depends only on current state, not prior history What is assumption if next state doesn’t depend on current state? We can also make transition dependent on some amount of history

Training Assume some amount of history (the ‘order’ of the Markov model) We need to fill in proper parameters, e.g., the transition probabilities These are inferred from a training set of trusted data On enough data, this provides maximum likelihood (ML) parameter values

Hidden Markov model Assume: a Markov model of a certain ‘type’ (set of parameters) Given: a set of data Find: the set of transitions most likely (ML) to have generated the data

The crooked casino One good die, one crooked die 1: 1/6 2: 1/6 3: 1/6 4: 1/6 5: 1/6 6: 1/6 1: 1/10 2: 1/10 3: 1/10 4: 1/10 5: 1/10 6: 1/

What we see in Atlantic City Two states: fair die (F) and loaded die (L) What we see: a sequence of rolls of the die What is hidden: the switching of the die (the state) We want to guess which die was most likely being used for each roll

Terminology Symbols: States: FFFFFFFFFFFFLLLLLLL The sequence of symbols is denoted x The sequence of states is called the path  The path is a Markov chain Probability of rolling b {1..6} with die k {F,L} is the emission probability e k (b) = P(x i = b |  i = k)

Probability of (x,  ) P(x,  ) = a 0  1  e  i (x i )a  i  i+1 So, finding the likelihood of a given sequence and path is easy Does this tell us when the casino switched dice? L i=1

Viterbi algorithm Intuition: find the most likely path for the observed sequence Method: backtracking 2D array –row: symbol for all states –column: observed symbol

V B 1 0 1f 0 0 2f 0 0 3f 0 0 4f 0 0 5f 0 0 6f l 0 0 2l 0 0 3l 0 0 4l 0 0 5l 0 0 6l 0 0.5