NEUROSCIENCE INSTITUTE AT STANFORD (NIS) September 27, 2004

NIS: The Rationale Disorders of the nervous are devastating and increasingly common. As a result of advances in basic research, we are learning to decipher disease mechanisms, encouraging prospects for effective new treatments. But, a variety of factors combine to slow the pace of applying the benefits of research to patient care. A NEW MODEL IS NEEDED TO ACCELERATE RESEARCH LEADING TO TREATMENTS

NIS: The Vision A new culture for neuroscience - that encourages dialogue between scientists, clinicians, patients and industry - that motivates and supports fundamental neuroscience research - that rapidly translates discoveries into enhanced care for those with disorders of the nervous system - and that sends the message that we are rededicating our efforts to the service of patients.

Outreach Education Clinical Care Basic Science Research Translational Research Clinical Research NIS To Integrate-To Translate-To Educate NIS: The Model

To Integrate -across disciplines -scientists and clinicians -professionals and patients/advocates -across academic institutions -academia, industry, government NIS: The Model

To Translate: A Re-Definition The process of applying ideas, insights, and discoveries generated through basic scientific inquiry to the treatment or prevention of human disease; AND The process of taking insights and ideas developed through the study of human disease to generate new scientific insights. Bench Bedside

Neurons Cognition Neuronal systems Genes Development Clinical trials Industry Delivery Health Care Neuroscience Translating Research Advances Academia Doesn’t Push: Industry Often Doesn’t Pull

Neurons Cognition Neuronal systems Genes Development Clinical trials Industry Delivery Health Care Science Translating Research Advances in the NIS Breaking Down Barriers to Progress

NIS: Why Now? We understand, as never before, how the brain is built and how it functions. We have powerful new tools to further elucidate brain structure and function. Recent advances have set the stage for significant improvements in diagnosis and treatment of nervous system disorders.

NIS: Why Here? The Stanford neuroscience community is recognized nationally and internationally for its contributions to basic and clinical science. It addresses all levels of nervous system investigation. Stanford neuroscientists recognize the enormous promise that its work holds for enhancing the lives of patients with neurological and mental disorders.

NIS: Why This Model? Because to accelerate progress the NIS must- Foster a culture that recognizes and supports the importance of fundamental and disease- relevant. Be able to integrate across all levels of analysis of brain function. Embrace physician-scientists, clinicians, patients and industry as vital to the effort.

NIS Cores Theme GroupsTraining Working Groups Outreach NIS: The Parts Exec. Cmte.Adv. Council

NIS: The Working Groups Involve scientists, clinicians, patients, industry -To focus on solving basic and/or clinical neuroscience problems -To define the “state of the field” -To point to knowledge gaps -To apply resources to fill those gaps -To accelerate development of tools and concepts -To accelerate translation to patient care

Investigators: Robert Malenka, Craig Garner, Irving Weissman, Barbara Sommer, Allan Reiss, Dick Tsien, William Mobley. “Abnormal Synaptic Structure and Function in Down Syndrome: Elucidating Genetic, Molecular and Cellular Mechanisms Leading to Treatments to Enhance Cognition” Working Group on Down Syndrome

Discovers genes and mechanisms Discovers treatments Defines the problems Delivers treatments THE WORKING GROUP

Stroke - Greg Albers, Gary Steinberg, Michael Moseley, Pak Chan, Robert Sapolsky Parkinson’s Disease - Theo Palmer, Rich Reimer, Helen Bronte-Stewart, Jamie Henderson Developmental Motor Disorders -Terry Sanger, Scott Delp, Krishna Chenoy Pain - Sean Mackey, Dave Yeomans Working Groups in the Making

Alzheimer’s Disease - Tony Wyss-Coray, Mike Grecius, Bill Mobley Multiple Sclerosis/Neural Regeneration - Ben Barres, Larry Steinman Brain Tumor - Larry Recht, Griff Harsh, Mark Schnitzer Sleep -Emmanuel Mignot, Craig Heller Epilepsy - Robert Fisher, John Huguenard Working Groups in the Making

Basic Interface Clinical Research Now Future NIS : The Expectation