Accurate Day 1 blood testing for SARS Securing a better future SARS 血漿 RNA 測試 保障美好明天
SARS detection by current tests 現有的 SARS 病毒測試方法
Anti-virus antibody testing in blood 病毒抗體測試 Indirect testing 間接 Positive after 14 days 14 日後才有用
Virus culture 病毒種植 Takes several days 需時數天
PolS EMN
Nasopharyngeal aspirate 鼻咽液 32% day 3 68% day 14 Faeces 糞便 97% day 14 Urine 尿液 42% day 15
New SARS blood test 新的 SARS 病毒血 液 測試
Why a blood test? 為何用血液 ?
PolS EMN SARS Plasma RNA test SARS 血漿 RNA 測試
Day 1 of hospital admission 入院後的首天 Detects 80% of all patients with SARS 準確識別 80% SARS 病人 Detects 100% of patients who will need ICU admission 準確預測需要深切治療的病人 No signal for non-SARS patients 沒有錯認非 SARS 病人
Quantitative Dimension 量化平核
ICU and non-ICU patients 深切治療 及 非深切治療 28 times increase
Outcome comparison 死亡個案比較 5 times increase
Serial Analysis 連續觀察
SARS CoV (copies/mL) Day non-ICU patient ICU patient
Future Applications 未來的應用 Guidance to drug treatment 藥物治療跟進 Testing to new drugs 新藥試驗 Virus load and infectivity 衡量病毒數量及傳播性
Conclusions 總結 Quantitative blood test 量化測試 Day 1 testing detects 80% of cases 準確 Day 1 testing reveals severity 預測嚴重性 Continuous monitoring 連續觀察 Powerful research tool 重要研究工具
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