Chapter 16 (Part 4) Synthesis of Eicosanoids, Glycerolipids and Isoprenoids.

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Presentation transcript:

Chapter 16 (Part 4) Synthesis of Eicosanoids, Glycerolipids and Isoprenoids

Eicosanoids

Eicosanoid Synthesis cyclooxygenase

Glycerolipid Biosynthesis

Mevalonate kinase Phosphomevalonate kinase pyrohosphomevalonate decarboxylase Formation of the isopentenyl pyrophosphate (IPP)

Two Fates of HMG-CoA

Condensation of IPP into Polyprenyl Compounds Dimethylallyl pryophosphate IPP isomerase

IPP Isomerase prenyltransferase Squalene synthase Cholesterol Synthesis from IPP

Squalene monooxygenase 2,3-oxidosqualene lanosterol cyclase cholesterol 20 steps

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